Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH044923-04
Application #
2246288
Study Section
Pharmacology A Study Section (PHRA)
Project Start
1992-03-01
Project End
1997-02-28
Budget Start
1995-03-01
Budget End
1997-02-28
Support Year
4
Fiscal Year
1995
Total Cost
Indirect Cost
Name
University of Texas Health Science Center Houston
Department
Biochemistry
Type
Schools of Medicine
DUNS #
City
Houston
State
TX
Country
United States
Zip Code
77225
Geng, J; Strobel, H W (1998) Expression, induction and regulation of the cytochrome P450 monooxygenase system in the rat glioma C6 cell line. Brain Res 784:276-83
Geng, J; Strobel, H W (1997) Expression and induction of cytochrome P-450 1A1 and P-450 2D subfamily in the rat glioma C6 cell line. Brain Res 774:11-9
Strobel, H W; Geng, J; Kawashima, H et al. (1997) Cytochrome P450-dependent biotransformation of drugs and other xenobiotic substrates in neural tissue. Drug Metab Rev 29:1079-105
Kawashima, H; Kusunose, E; Thompson, C M et al. (1997) Protein expression, characterization, and regulation of CYP4F4 and CYP4F5 cloned from rat brain. Arch Biochem Biophys 347:148-54
Thompson, C M; Bernhard, A E; Strobel, H W (1997) Barbiturate-induced expression of neuronal nitric oxide synthase in the rat cerebellum. Brain Res 754:142-6
Baum, L O; Strobel, H W (1997) Regulation of expression of cytochrome P-450 2D mRNA in rat brain with steroid hormones. Brain Res 765:67-73
Wang, H; Strobel, H W (1997) Regulation of CYP3A9 gene expression by estrogen and catalytic studies using cytochrome P450 3A9 expressed in Escherichia coli. Arch Biochem Biophys 344:365-72
Sequeira, D J; Strobel, H W (1996) In vitro metabolism of imipramine by brain microsomes: effects of inhibitors and exogenous cytochrome P450 reductase. Brain Res 738:24-31
Wang, H; Kawashima, H; Strobel, H W (1996) cDNA cloning of a novel CYP3A from rat brain. Biochem Biophys Res Commun 221:157-62
Kawashima, H; Sequeira, D J; Nelson, D R et al. (1996) Genomic cloning and protein expression of a novel rat brain cytochrome P-450 CYP2D18* catalyzing imipramine N-demethylation. J Biol Chem 271:28176-80

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