Abstract

Schizophrenia is a relatively frequent and disabling disease of variable expression and unknown, but perhaps heterogeneous cause. Definition of subtypes and pathogenesis-symptom complex relationships are prerequisites to advances in therapeutics and prevention. The objective of our research is to test the hypothesis of heterogeneity by searching for genetically validated subtypes. To this end, we have collected from an epidemiologic sample, a large number of families with more than on affected member. We now propose a genetic study of these families using recombinant DNA methods. In addition to candidate gene and chromosome specific probes, we will use cytogenetic and biochemical polymorphisms to look for linkages and associations which will suggest areas of specific chromosomes to examine with relevant probes. Associations of clinical expression with specific genes would form a useful basis for a classification of the types of schizophrenia.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH045588-02
Application #
3385402
Study Section
Special Emphasis Panel (SRCM)
Project Start
1989-02-01
Project End
1993-01-31
Budget Start
1990-03-01
Budget End
1991-01-31
Support Year
2
Fiscal Year
1990
Total Cost
Indirect Cost

  Institution

Name
Johns Hopkins University
Department
Type
Schools of Medicine
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218

  Publications

Glidden, David V; Liang, Kung-Yee; Chiu, Yen-Feng et al. (2003) Multipoint affected sibpair linkage methods for localizing susceptibility genes of complex diseases. Genet Epidemiol 24:107-17
Blouin, J L; Dombroski, B A; Nath, S K et al. (1998) Schizophrenia susceptibility loci on chromosomes 13q32 and 8p21. Nat Genet 20:70-3
Pulver, A E; Wolyniec, P S; Housman, D et al. (1996) The Johns Hopkins University Collaborative Schizophrenia Study: an epidemiologic-genetic approach to test the heterogeneity hypothesis and identify schizophrenia susceptibility genes. Cold Spring Harb Symp Quant Biol 61:797-814
Antonarakis, S E; Blouin, J L; Pulver, A E et al. (1995) Schizophrenia susceptibility and chromosome 6p24-22. Nat Genet 11:235-6
Lasseter, V K; Pulver, A E; Wolyniec, P S et al. (1995) Follow-up report of potential linkage for schizophrenia on chromosome 22q: Part 3. Am J Med Genet 60:172-3
Lindsay, E A; Morris, M A; Gos, A et al. (1995) Schizophrenia and chromosomal deletions within 22q11.2. Am J Hum Genet 56:1502-3
Karayiorgou, M; Morris, M A; Morrow, B et al. (1995) Schizophrenia susceptibility associated with interstitial deletions of chromosome 22q11. Proc Natl Acad Sci U S A 92:7612-6
Pulver, A E; Lasseter, V K; Kasch, L et al. (1995) Schizophrenia: a genome scan targets chromosomes 3p and 8p as potential sites of susceptibility genes. Am J Med Genet 60:252-60
Karayiorgou, M; Kasch, L; Lasseter, V K et al. (1994) Report from the Maryland Epidemiology Schizophrenia Linkage Study: no evidence for linkage between schizophrenia and a number of candidate and other genomic regions using a complex dominant model. Am J Med Genet 54:345-53
Melton, B; Liang, K Y; Pulver, A E (1994) Extended latent class approach to the study of familial/sporadic forms of a disease: its application to the study of the heterogeneity of schizophrenia. Genet Epidemiol 11:311-27

Showing the most recent 10 out of 17 publications