Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH045812-03
Application #
2246788
Study Section
Neurosciences Research Review Committee (BPN)
Project Start
1990-06-01
Project End
1995-12-31
Budget Start
1992-06-01
Budget End
1995-12-31
Support Year
3
Fiscal Year
1992
Total Cost
Indirect Cost
Name
Loyola University Chicago
Department
Pharmacology
Type
Schools of Medicine
DUNS #
791277940
City
Maywood
State
IL
Country
United States
Zip Code
60153
Van de Kar, L D; Levy, A D; Li, Q et al. (1998) A comparison of the oxytocin and vasopressin responses to the 5-HT1A agonist and potential anxiolytic drug alnespirone (S-20499). Pharmacol Biochem Behav 60:677-83
Van de Kar, L D; Li, Q; Cabrera, T M et al. (1998) Alterations in 8-hydroxy-2-(dipropylamino)tetralin-induced neuroendocrine responses after 5,7-dihydroxytryptamine-induced denervation of serotonergic neurons. J Pharmacol Exp Ther 286:256-62
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Li, Q; Muma, N A; Battaglia, G et al. (1997) A desensitization of hypothalamic 5-HT1A receptors by repeated injections of paroxetine: reduction in the levels of G(i) and G(o) proteins and neuroendocrine responses, but not in the density of 5-HT1A receptors. J Pharmacol Exp Ther 282:1581-90
Li, Q; Muma, N A; van de Kar, L D (1996) Chronic fluoxetine induces a gradual desensitization of 5-HT1A receptors: reductions in hypothalamic and midbrain Gi and G(o) proteins and in neuroendocrine responses to a 5-HT1A agonist. J Pharmacol Exp Ther 279:1035-42
Saydoff, J A; Rittenhouse, P A; Carnes, M et al. (1996) Neuroendocrine and cardiovascular effects of serotonin: selective role of brain angiotensin on vasopressin. Am J Physiol 270:E513-21
Li, Q; Murakami, I; Stall, S et al. (1996) Neuroendocrine pharmacology of three serotonin releasers: 1-(1,3-benzodioxol-5-yl)-2-(methylamino)butane (MBDB), 5-methoxy-6-methyl-2-aminoindan (MMAi) and p-methylthioamphetamine (MTA). J Pharmacol Exp Ther 279:1261-7
Van de Kar, L D; Rittenhouse, P A; Li, Q et al. (1995) Hypothalamic paraventricular, but not supraoptic neurons, mediate the serotonergic stimulation of oxytocin secretion. Brain Res Bull 36:45-50
Ghosh, R; Sladek, C D (1995) Role of prolactin and gonadal steroids in regulation of oxytocin mRNA during lactation. Am J Physiol 269:E76-84

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