The present application proposes a program of studies organized around four broad issues dealing with the clinical, cognitive, functional, and neurophysiological significance of electrodermal activity and prepulse inhibition (PPI) of the startle eyeblink reflex. The four issues involve testing predictions derived from a vulnerability stress model of schizophrenia. The first (clinical) issue is whether anomalies in tonic electrodermal activity index a """"""""transient intermediate state"""""""" that precedes symptomatic episodes in vulnerable individuals. The second (cognitive) issue is whether PPI can index both automatic and controlled cognitive processes when tested in the investigator's """"""""attention-to-prepulse"""""""" paradigm. The third (functional) issue concerns whether PPI reflects a sensory inhibition process, while phasic electrodermal responses reflect sensory intake. A fourth (neurophysiological) issue addresses whether brain structural abnormalities are related to electrodermal and PPI anomalies in schizophrenia. These four issues will be tested in randomly selected college students, those selected to be putatively """"""""at-risk"""""""" and in schizophrenic outpatients.
| Dawson, Michael E; Schell, Anne M; Rissling, Anthony et al. (2010) Psychophysiological prodromal signs of schizophrenic relapse: a pilot study. Schizophr Res 123:64-7 |
| Cosand, Louise D; Cavanagh, Thomas M; Brown, Ashley A et al. (2008) Arousal, working memory, and conscious awareness in contingency learning. Conscious Cogn 17:1105-13 |
| Hazlett, Erin A; Dawson, Michael E; Schell, Anne M et al. (2008) Probing attentional dysfunctions in schizophrenia: Startle modification during a continuous performance test. Psychophysiology 45:632-42 |
| Rissling, Anthony J; Dawson, Michael E; Schell, Anne M et al. (2007) Effects of cigarette smoking on prepulse inhibition, its attentional modulation, and vigilance performance. Psychophysiology 44:627-34 |
| Thorne, Gary L; Dawson, Michael E; Schell, Anne M (2006) Effects of perceptual load on startle reflex modification at a long lead interval. Psychophysiology 43:498-503 |
| Rissling, Anthony J; Dawson, Michael E; Schell, Anne M et al. (2005) Effects of perceptual processing demands on startle eyeblink modification. Psychophysiology 42:440-6 |
| Thorne, Gary L; Dawson, Michael E; Schell, Anne M (2005) Attention and prepulse inhibition: the effects of task-relevant, irrelevant, and no-task conditions. Int J Psychophysiol 56:121-8 |
| Schell, Anne M; Dawson, Michael E; Rissling, Anthony et al. (2005) Electrodermal predictors of functional outcome and negative symptoms in schizophrenia. Psychophysiology 42:483-92 |
| Wynn, Jonathan K; Sergi, Mark J; Dawson, Michael E et al. (2005) Sensorimotor gating, orienting and social perception in schizophrenia. Schizophr Res 73:319-25 |
| Wynn, Jonathan K; Dawson, Michael E; Schell, Anne M (2004) The functional relationship between visual backward masking and prepulse inhibition. Psychophysiology 41:306-12 |
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