This continuation project is designed primarily to explore the relationship between central serotonergic (5-HT) function and aggressive behavior in children with and without attention-deficit hyperactivity disorder (ADHD). Central 5-HT will be assessed by measuring the prolactin response to a challenge dose of the 5-HT releaser/reuptake inhibitor fenfluramine, as compared to a placebo challenge. The primary goal is to extend the previous assessment of central 5-HT function to aggressive non- ADHD children and normal controls, in addition to new groups of aggressive and non-aggressive ADHD children. Secondarily, the symptom dimensions of impulsivity and hyperactivity will be assessed to determine their differential relationships with central 5-HT junction and aggression, and the relationship between academic achievement and the norepinephrine metabolite MHPG will be examined in ADHD and non-ADHD children. Children participating in this study will be divided into four groups of seven to eleven year-old boys: ADHD non-aggressive (N = 20), ADHD aggressive (N = 20), aggressive non-ADHD (N = 20) and normal controls (N= 20). The primary questions that will be addressed in this study are: 1. Is the difference in prolactin (PRL) response to fenfluramine (FEN) between aggressive and non-aggressive ADHD children due to an enhanced response relative to normals in aggressive ADHD children, a diminished response in non-aggressive ADHD children relative to normals, or is the PRL response to FEN in both aggressive and non-aggressive ADHD children different from that of normal children? 2. Is the enhanced PRL response to FEN challenge in aggressive, relative to non-aggressive, ADHD children related to an interaction between ADHD and aggression or is it characteristic of aggressive behavior in children irrespective of ADHD? Secondary aims of this project are a) to determine whether-the relationship between the PRL response to FEN and measures of impulsivity and activity level are similar or different in ADHD and non-ADHD patient groups; and b) to replicate the previous finding of an inverse relationship between plasma MHPG and measures of academic achievement in ADHD children, and to determine whether this relationship is limited to children with ADHD.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH046448-05
Application #
2247056
Study Section
Child Psychopathology and Treatment Review Committee (CPT)
Project Start
1990-08-01
Project End
1998-04-30
Budget Start
1995-05-01
Budget End
1996-04-30
Support Year
5
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Queens College
Department
Psychology
Type
Schools of Arts and Sciences
DUNS #
City
Flushing
State
NY
Country
United States
Zip Code
11367
Ivanov, Iliyan; Flory, Janine; Newcorn, Jeffrey H et al. (2018) Childhood serotonergic function and early adult outcomes in youth with ADHD: A 15-year follow-up study. Eur Neuropsychopharmacol 28:1429-1438
Trampush, Joey W; Jacobs, Michelle M; Hurd, Yasmin L et al. (2014) Moderator effects of working memory on the stability of ADHD symptoms by dopamine receptor gene polymorphisms during development. Dev Sci 17:584-95
Harty, Seth C; Galanopoulos, Stavroula; Newcorn, Jeffrey H et al. (2013) Delinquency, aggression, and attention-related problem behaviors differentially predict adolescent substance use in individuals diagnosed with ADHD. Am J Addict 22:543-50
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Harty, Seth C; Ivanov, Iliyan; Newcorn, Jeffrey H et al. (2011) The impact of conduct disorder and stimulant medication on later substance use in an ethnically diverse sample of individuals with attention-deficit/hyperactivity disorder in childhood. J Child Adolesc Psychopharmacol 21:331-9
Nomura, Yoko; Marks, David J; Halperin, Jeffrey M (2010) Prenatal exposure to maternal and paternal smoking on attention deficit hyperactivity disorders symptoms and diagnosis in offspring. J Nerv Ment Dis 198:672-8
Bédard, Anne-Claude V; Trampush, Joey W; Newcorn, Jeffrey H et al. (2010) Perceptual and motor inhibition in adolescents/young adults with childhood-diagnosed ADHD. Neuropsychology 24:424-34
Harty, Seth C; Miller, Carlin J; Newcorn, Jeffrey H et al. (2009) Adolescents with childhood ADHD and comorbid disruptive behavior disorders: aggression, anger, and hostility. Child Psychiatry Hum Dev 40:85-97
Halperin, Jeffrey M; Trampush, Joey W; Miller, Carlin J et al. (2008) Neuropsychological outcome in adolescents/young adults with childhood ADHD: profiles of persisters, remitters and controls. J Child Psychol Psychiatry 49:958-66

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