The proposed project is a clinical trial of three different psychotherapeutic interventions for adolescent suicide attempters with RDC major depression. One hundred twenty (120) nonpsychotic, non-bipolar depressed suicide attempters aged 13-18, will be randomly assigned to one of three treatments: (1) cognitive-behavioral therapy (CBI); (2) systemic-behavioral family therapy (SBFT); or (3) non-directive supportive therapy. Treatment will be 12-16 sessions in length to be delivered over a 12 week period, and will be monitored for integrity with the therapeutic model through intensive training and supervision, use of therapy manual, and monitoring a rating of videotaped sessions.
The aims of the study are to test the following hypotheses: (1) Patients treated with CBT and SBFR relative to patients treated with NST will show greater improvements in the prevalence and severity of depression and suicidality and in social competence, (2) At 3, 6, 9, and 12 month follow-up, CBT- and SBFr-treated patients will continue to show decreased prevalence and severity of depression and suicidality and superior social competency compared to NST-treated patients. Those factors predictive of responses to CBT vs. SBFR will also be explored.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH046500-03
Application #
3386323
Study Section
Treatment Development and Assessment Research Review Committee (TDA)
Project Start
1991-02-01
Project End
1996-01-31
Budget Start
1993-02-01
Budget End
1994-01-31
Support Year
3
Fiscal Year
1993
Total Cost
Indirect Cost
Name
University of Pittsburgh
Department
Type
Schools of Medicine
DUNS #
053785812
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
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Bridge, Jeffrey A; Barbe, Remy P; Birmaher, Boris et al. (2005) Emergent suicidality in a clinical psychotherapy trial for adolescent depression. Am J Psychiatry 162:2173-5
Barbe, Remy P; Bridge, Jeffrey; Birmaher, Boris et al. (2004) Suicidality and its relationship to treatment outcome in depressed adolescents. Suicide Life Threat Behav 34:44-55
Gaynor, Scott T; Weersing, V Robin; Kolko, David J et al. (2003) The prevalence and impact of large sudden improvements during adolescent therapy for depression: a comparison across cognitive-behavioral, family, and supportive therapy. J Consult Clin Psychol 71:386-93
Brent, D A; Birmaher, B; Kolko, D et al. (2001) Subsyndromal depression in adolescents after a brief psychotherapy trial: course and outcome. J Affect Disord 63:51-8
Brent, D A (2001) Firearms and suicide. Ann N Y Acad Sci 932:225-39; discussion; 239-40
Stein, D; Brent, D A; Bridge, J et al. (2001) Predictors of parent-rated credibility in a clinical psychotherapy trial for adolescent depression. J Psychother Pract Res 10:1-7
Brent, D A (2001) Assessment and treatment of the youthful suicidal patient. Ann N Y Acad Sci 932:106-28; discussion 128-31
Birmaher, B; Brent, D A; Kolko, D et al. (2000) Clinical outcome after short-term psychotherapy for adolescents with major depressive disorder. Arch Gen Psychiatry 57:29-36
Kolko, D J; Brent, D A; Baugher, M et al. (2000) Cognitive and family therapies for adolescent depression: treatment specificity, mediation, and moderation. J Consult Clin Psychol 68:603-14

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