Several abnormal neuropsychiatric traits are more prevalent among the nonschizophrenic biological relatives of schizophrenics than is clinical schizophrenia. Prominent among such potential expressions of """"""""latent liability"""""""" are eye movement dysfunctions, thought disorder, and schizophrenia spectrum disorders and traits. The availability of alternative, more prevalent manifestations of the schizophrenia genotype would increase the power of linkage studies by broadening the pool of informative families. To be optimally informative for linkage studies, however, methods for accurately measuring these traits need to be established, including information about their distribution, specificity, stability, and interrelatedness. Each of these traits has been studied extensively in schizophrenics and their family members. This study addresses the co-aggregation within the same individuals of these traits and their individual and collective usefulness in discriminating 105 schizophrenics from 105 normal controls and 75 siblings of schizophrenics from 75 sibling of controls. We will use the discriminant analysis, logistic regression, multivariate analysis of variance, and normal mixture models to compare schizophrenics with normal controls and siblings of schizophrenics with siblings of normals. These data complement those from the McLean Schizophrenia Collaborative Project (""""""""Collaborative Biological Research in Schizophrenia""""""""; MH 31154), which is studying the co-aggregation of these traits (and others) within families of schizophrenics, but in a different family design.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH049487-02
Application #
3388831
Study Section
Psychopathology and Clinical Biology Research Review Committee (PCB)
Project Start
1992-06-01
Project End
1996-05-31
Budget Start
1993-06-01
Budget End
1994-05-31
Support Year
2
Fiscal Year
1993
Total Cost
Indirect Cost
Name
Mc Lean Hospital (Belmont, MA)
Department
Type
DUNS #
City
Belmont
State
MA
Country
United States
Zip Code
02478
Morgan, Charity J; Coleman, Michael J; Ulgen, Ayse et al. (2017) Thought Disorder in Schizophrenia and Bipolar Disorder Probands, Their Relatives, and Nonpsychiatric Controls. Schizophr Bull 43:523-535
Deutsch, Curtis K; Levy, Deborah L; Price, Selya F R et al. (2015) Quantitative Measures of Craniofacial Dysmorphology in a Family Study of Schizophrenia and Bipolar Illness. Schizophr Bull 41:1309-16
Morgan, Charity J; Lenzenweger, Mark F; Rubin, Donald B et al. (2014) A hierarchical finite mixture model that accommodates zero-inflated counts, non-independence, and heterogeneity. Stat Med 33:2238-50
Coleman, Michael J; Titone, Debra; Krastoshevsky, Olga et al. (2010) Reinforcement ambiguity and novelty do not account for transitive inference deficits in schizophrenia. Schizophr Bull 36:1187-200
Krause, Verena; Krastoshevsky, Olga; Coleman, Michael J et al. (2010) Tailoring the definition of the clinical schizophrenia phenotype in linkage studies. Schizophr Res 116:133-42
Coleman, Michael J; Cestnick, Laurie; Krastoshevsky, Olga et al. (2009) Schizophrenia patients show deficits in shifts of attention to different levels of global-local stimuli: evidence for magnocellular dysfunction. Schizophr Bull 35:1108-16
Chen, Yue; Grossman, Emily D; Bidwell, L Cinnamon et al. (2008) Differential activation patterns of occipital and prefrontal cortices during motion processing: evidence from normal and schizophrenic brains. Cogn Affect Behav Neurosci 8:293-303
Ulgen, Ayse; Yoo, Yun Joo; Gordon, Derek et al. (2004) Percentiles of the null distribution of 2 maximum lod score tests. Hum Hered 57:39-48
Levy, Deborah L; O'Driscoll, Gillian; Matthysse, Steven et al. (2004) Antisaccade performance in biological relatives of schizophrenia patients: a meta-analysis. Schizophr Res 71:113-25
Titone, Debra; Ditman, Tali; Holzman, Philip S et al. (2004) Transitive inference in schizophrenia: impairments in relational memory organization. Schizophr Res 68:235-47

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