Abstract

This research will establish whether obsessive compulsive disorder (OCD) is familial. Given the inconsistencies and methodological limitations of prior research, we are proposing a blinded, controlled family study. Additional aims include: determining if other specific psychiatric disorders are more prevalent in first-degree relatives of OCD probands than those of controls; identifying demographic and clinical features which distinguish familial from sporadic (non-familial) cases of OCD; and conducting segregation analysis. OCD probands will be identified in four institutions in Baltimore and Washington, D.C. A control group, matched on age, sex, and race, will be identified in the residential neighborhood of each proband. All probands, controls, and their first-degree relatives will be directly and blindly examined using a standardized instrument to diagnose DSM-IIIR Axis I and Axis II psychiatric disorders. Final diagnoses will be made by consensus of two independent psychiatrists reviewing all case material, including medical records. Families with multiple affected members with OCD will be identified to possible future genetic linkage study.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH050214-03
Application #
2430951
Study Section
Special Emphasis Panel (SRCM (20))
Project Start
1995-06-01
Project End
1999-05-31
Budget Start
1997-06-01
Budget End
1998-05-31
Support Year
3
Fiscal Year
1997
Total Cost
Indirect Cost

  Institution

Name
Johns Hopkins University
Department
Psychiatry
Type
Schools of Medicine
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218

  Publications

Samuels, Jack; Bienvenu, O Joseph; Krasnow, Janice et al. (2017) An investigation of doubt in obsessive-compulsive disorder. Compr Psychiatry 75:117-124
Chen, David; Bienvenu, O Joseph; Krasnow, Janice et al. (2017) Parental bonding and hoarding in obsessive-compulsive disorder. Compr Psychiatry 73:43-52
Riddle, Mark A; Maher, Brion S; Wang, Ying et al. (2016) OBSESSIVE-COMPULSIVE PERSONALITY DISORDER: EVIDENCE FOR TWO DIMENSIONS. Depress Anxiety 33:128-35
Guglielmi, Valeria; Vulink, Nienke C C; Denys, Damiaan et al. (2014) Obsessive-compulsive disorder and female reproductive cycle events: results from the OCD and reproduction collaborative study. Depress Anxiety 31:979-87
Samuels, Jack; Shugart, Yin Yao; Wang, Ying et al. (2014) Clinical correlates and genetic linkage of social and communication difficulties in families with obsessive-compulsive disorder: Results from the OCD Collaborative Genetics Study. Am J Med Genet B Neuropsychiatr Genet 165B:326-36
Samuels, Jack; Grados, Marco A; Riddle, Mark A et al. (2014) Hoarding in Children and Adolescents with Obsessive-Compulsive Disorder. J Obsessive Compuls Relat Disord 3:325-331
Davis, Lea K; Yu, Dongmei; Keenan, Clare L et al. (2013) Partitioning the heritability of Tourette syndrome and obsessive compulsive disorder reveals differences in genetic architecture. PLoS Genet 9:e1003864
Stewart, S E; Mayerfeld, C; Arnold, P D et al. (2013) Meta-analysis of association between obsessive-compulsive disorder and the 3' region of neuronal glutamate transporter gene SLC1A1. Am J Med Genet B Neuropsychiatr Genet 162B:367-79
Nestadt, G; Wang, Y; Grados, M A et al. (2012) Homeobox genes in obsessive-compulsive disorder. Am J Med Genet B Neuropsychiatr Genet 159B:53-60
Voyiaziakis, E; Evgrafov, O; Li, D et al. (2011) Association of SLC6A4 variants with obsessive-compulsive disorder in a large multicenter US family study. Mol Psychiatry 16:108-20

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