Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
2R01MH050426-04
Application #
2249756
Study Section
Psychobiological, Biological, and Neurosciences Subcommittee (MHAI)
Project Start
1993-02-01
Project End
2001-01-31
Budget Start
1996-03-01
Budget End
1997-01-31
Support Year
4
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Scripps Research Institute
Department
Type
DUNS #
City
La Jolla
State
CA
Country
United States
Zip Code
92037
Campbell, Iain L; Hofer, Markus J; Pagenstecher, Axel (2010) Transgenic models for cytokine-induced neurological disease. Biochim Biophys Acta 1802:903-17
Molinero, Amalia; Penkowa, Milena; Hernandez, Joaquin et al. (2003) Metallothionein-I overexpression decreases brain pathology in transgenic mice with astrocyte-targeted expression of interleukin-6. J Neuropathol Exp Neurol 62:315-28
Penkowa, Milena; Camats, Jordi; Giralt, Mercedes et al. (2003) Metallothionein-I overexpression alters brain inflammation and stimulates brain repair in transgenic mice with astrocyte-targeted interleukin-6 expression. Glia 42:287-306
Carrasco, Javier; Penkowa, Milena; Giralt, Mercedes et al. (2003) Role of metallothionein-III following central nervous system damage. Neurobiol Dis 13:22-36
Samland, Helen; Huitron-Resendiz, Salvador; Masliah, Eliezer et al. (2003) Profound increase in sensitivity to glutamatergic- but not cholinergic agonist-induced seizures in transgenic mice with astrocyte production of IL-6. J Neurosci Res 73:176-87
Campbell, I L (2002) Cytokine-mediated inflammation and other actions in the central nervous system. Ernst Schering Res Found Workshop :61-83
Wang, J; Asensio, V C; Campbell, I L (2002) Cytokines and chemokines as mediators of protection and injury in the central nervous system assessed in transgenic mice. Curr Top Microbiol Immunol 265:23-48
Strack, Andreas; Schluter, Dirk; Asensio, Valerie C et al. (2002) Regulation of the kinetics of intracerebral chemokine gene expression in murine Toxoplasma encephalitis: impact of host genetic factors. Glia 40:372-7
Strack, Andreas; Asensio, Valerie C; Campbell, Iain L et al. (2002) Chemokines are differentially expressed by astrocytes, microglia and inflammatory leukocytes in Toxoplasma encephalitis and critically regulated by interferon-gamma. Acta Neuropathol (Berl) 103:458-68
Milner, Richard; Campbell, Iain L (2002) Cytokines regulate microglial adhesion to laminin and astrocyte extracellular matrix via protein kinase C-dependent activation of the alpha6beta1 integrin. J Neurosci 22:1562-72

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