Personality disorders are characteristic patterns of perceiving the world, emotional responsiveness, interpersonal functioning, and impulse control that are maladaptive, pervasive, and inflexible. Individuals with these disorders make like difficult for themselves, those close to them, and society at large. Evaluating these disorders is crucial for clinicians in understanding patients, predicting course, and optimizing treatment. However, there is insufficient empirical support for how best to conceptualize and measure these disorders, and the relationship between 'normal' personality, disordered personality, and other pyschopathology is unclear. We have assembled a unique and important dataset for investigating these issues in a well-characterized sample of individuals who were not selected for treatment. In the previous grant period, we used multiple methods of assessment to characterize the personality structure and psychiatric history of 742 subjects. These subjects have had additional assessments over a 17-year period, as part of the Baltimore Epidemiologic Catchment Area (EGA) and Follow-up studies. To our knowledge, the range of psychopathology assessed, and the range of methods of assessment, is broader than in any other sample. The range of psychopathology assessed includes virtually all axis I and axis II signs, symptoms, traits, and disorders, as well as dimensional measures of normal variation in personality. The assessment methods included psychiatrists using the Schedules for Clinical Assessment in Neuropsychiatry (SCAN), master's level psychologists using the International Personality Disorder Examination (IPDE), and the report of significant others as well as self report. The overall goal of the study is to enhance knowledge about the structure of different conceptualizations of personality disorder, their relationships to normal personality and to psychopathology, and their association with measures of disability, selected risk factors, including genetic polymorphisms. Building on our previous contributions, this proposal applies innovative constructs of disordered personality and rigorous analytic strategies.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
2R01MH050616-06A2
Application #
6930058
Study Section
Behavioral Genetics and Epidemiology Study Section (BGES)
Program Officer
Bourdon, Karen H
Project Start
1996-09-15
Project End
2009-02-28
Budget Start
2005-05-01
Budget End
2006-02-28
Support Year
6
Fiscal Year
2005
Total Cost
$288,594
Indirect Cost
Name
Johns Hopkins University
Department
Psychiatry
Type
Schools of Medicine
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Lee, Hochang Benjamin; Offidani, Emanuela; Ziegelstein, Roy C et al. (2014) Five-factor model personality traits as predictors of incident coronary heart disease in the community: a 10.5-year cohort study based on the Baltimore epidemiologic catchment area follow-up study. Psychosomatics 55:352-361
Hock, Rebecca S; Lee, Hochang Benjamin; Bienvenu, O Joseph et al. (2014) Personality and cognitive decline in the Baltimore Epidemiologic Catchment Area follow-up study. Am J Geriatr Psychiatry 22:917-25
Park, Subin; Hong, Jin Pyo; Lee, Hochang B et al. (2012) Relationship between personality disorder dimensions and verbal memory functioning in a community population. Psychiatry Res 196:109-14
Nestadt, G; Di, C; Samuels, J F et al. (2012) Concordance between personality disorder assessment methods. Psychol Med 42:657-67
Rasic, Daniel; Robinson, Jennifer A; Bolton, James et al. (2011) Longitudinal relationships of religious worship attendance and spirituality with major depression, anxiety disorders, and suicidal ideation and attempts: findings from the Baltimore epidemiologic catchment area study. J Psychiatr Res 45:848-54
Blom, Rianne M; Samuels, Jack F; Riddle, Mark A et al. (2011) Association between a serotonin transporter promoter polymorphism (5HTTLPR) and personality disorder traits in a community sample. J Psychiatr Res 45:1153-9
Reti, Irving M; Xu, Jerry Z; Yanofski, Jason et al. (2011) Monoamine oxidase A regulates antisocial personality in whites with no history of physical abuse. Compr Psychiatry 52:188-94
Di, Chong-Zhi; Bandeen-Roche, Karen (2011) Multilevel latent class models with dirichlet mixing distribution. Biometrics 67:86-96
Lee, Hochang Benjamin; Bienvenu, O Joseph; Cho, Seong-Jin et al. (2010) Personality disorders and traits as predictors of incident cardiovascular disease: findings from the 23-year follow-up of the Baltimore ECA study. Psychosomatics 51:289-96
Nestadt, Gerald; Di, Chongzhi; Samuels, J F et al. (2010) The stability of DSM personality disorders over twelve to eighteen years. J Psychiatr Res 44:1-7

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