This application is a revision of an application for 5 years continuation that was submitted in 1999. At that time a one year extension was awarded; this application is for four years. The overall aim of this study is to provide a comprehensive picture of the course and outcome of four specific personality disorders (PDs): schizotypal (STPD), borderline (BPD), avoidant (AVPD), and obsessive-compulsive (OCPD). The present application continues a multi-site collaborative effort to follow a carefully diagnosed sample of 668 subjects having either these representative PDs or major depressive disorder (MDD) (controls) for the period from 3 to a maximum of 6 years after recruitment. Sixty new minority subjects will be recruited and followed for at least 2 years. Using a prospective, longitudinal, repeated measures design, we will develop the same basic knowledge about course and outcome for the PDs that has previously resulted from similar investigations of affective and anxiety disorders, thus addressing an important gap in our knowledge. The extended period of follow-up is essential to discern clinically meaningful descriptions of course and outcome and their determinants. The sample is large enough and sufficiently diverse demographically to attain a unique array of results generalizable to most clinical settings. To accomplish our overall aim, we propose three approaches: I. descriptive, II. predictive, and III. validating. The descriptive approach will provide data on diagnostic stability of PDs, on presence and course of comorbid Axis I disorders, on persistence of functional impairment, and on utilization of health care resources that allow comparison between the PDs and to similar data on Axis I disorders. The predictive approach will identify clinically meaningful determinants of prognosis within and across PDs. The validating approach will examine the homogeneity of descriptive and longitudinal features for the PDs.

National Institute of Health (NIH)
National Institute of Mental Health (NIMH)
Research Project (R01)
Project #
Application #
Study Section
Special Emphasis Panel (ZMH1-NRB-G (02))
Program Officer
Breiling, James P
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Mc Lean Hospital (Belmont, MA)
United States
Zip Code
Timoney, Linden R; Walsh, Zach; Shea, M Tracie et al. (2017) Personality and life events in a personality disorder sample. Personal Disord 8:376-382
Wright, Aidan G C; Hopwood, Christopher J; Skodol, Andrew E et al. (2016) Longitudinal validation of general and specific structural features of personality pathology. J Abnorm Psychol 125:1120-1134
Keuroghlian, Alex S; Gunderson, John G; Pagano, Maria E et al. (2015) Interactions of borderline personality disorder and anxiety disorders over 10 years. J Clin Psychiatry 76:1529-34
Ruocco, Anthony C; Hudson, James I; Zanarini, Mary C et al. (2015) Familial aggregation of candidate phenotypes for borderline personality disorder. Personal Disord 6:75-80
Ansell, Emily B; Wright, Aidan G C; Markowitz, John C et al. (2015) Personality disorder risk factors for suicide attempts over 10 years of follow-up. Personal Disord 6:161-7
Thomas, Katherine M; Hopwood, Christopher J; Donnellan, M Brent et al. (2014) Personality heterogeneity in PTSD: distinct temperament and interpersonal typologies. Psychol Assess 26:23-34
Hopwood, Christopher J; Morey, Leslie C; Donnellan, M Brent et al. (2013) Ten-year rank-order stability of personality traits and disorders in a clinical sample. J Pers 81:335-44
Grilo, Carlos M; Pagano, Maria E; Stout, Robert L et al. (2012) Stressful life events predict eating disorder relapse following remission: six-year prospective outcomes. Int J Eat Disord 45:185-92
Morey, L C; Hopwood, C J; Markowitz, J C et al. (2012) Comparison of alternative models for personality disorders, II: 6-, 8- and 10-year follow-up. Psychol Med 42:1705-13
McDevitt-Murphy, Meghan E; Shea, M Tracie; Yen, Shirley et al. (2012) Prospective investigation of a PTSD personality typology among individuals with personality disorders. Compr Psychiatry 53:441-50

Showing the most recent 10 out of 40 publications