The overall aim of this study is to provide a comprehensive picture of the course and outcome of four specific personality disorders (PDs): schizotypal (STPD), borderline (BPI)), avoidant (AVPD), and obsessive-compulsive (OCPD). The present proposal continues a multi-site collaborative effort to follow a carefully diagnosed sample of 668 subjects having either these representative PDs or major depressive disorder (MDD) (controls) for the period from 2 to a minimum of 6 years after recruitment. Using a prospective, longitudinal, repeated measures design, we will develop the same basic knowledge about course and outcome for the PDs that has previously resulted from similar investigations of affective and anxiety disorders, thus addressing an important gap in our knowledge. The extended period of follow-up is essential to discern clinically meaningful descriptions of course and outcome and their determinants. The sample is large enough and sufficiently diverse demographically to attain a unique array of results generalized to most clinical settings. To accomplish out overall aim, we propose three approached I. Descriptive, II. Predictive, and III. Validating. The descriptive approach will provide data on diagnostic stability of PDs, on presence and course of comorbid Axis I disorders, on persistence of functional impairment, and on utilization of health care resources that allow comparison between the PDs and similar data on Axis I disorders. The predictive approach will identify clinically meaningful determinants of prognosis within and across PDs. The validating approach will examine the homogeneity of descriptive and longitudinal features for the PDs, as defined by the DSM system, and how this compares with alternative schemes.
| Timoney, Linden R; Walsh, Zach; Shea, M Tracie et al. (2017) Personality and life events in a personality disorder sample. Personal Disord 8:376-382 |
| Wright, Aidan G C; Hopwood, Christopher J; Skodol, Andrew E et al. (2016) Longitudinal validation of general and specific structural features of personality pathology. J Abnorm Psychol 125:1120-1134 |
| Keuroghlian, Alex S; Gunderson, John G; Pagano, Maria E et al. (2015) Interactions of borderline personality disorder and anxiety disorders over 10 years. J Clin Psychiatry 76:1529-34 |
| Ansell, Emily B; Wright, Aidan G C; Markowitz, John C et al. (2015) Personality disorder risk factors for suicide attempts over 10 years of follow-up. Personal Disord 6:161-7 |
| Samuel, Douglas B; Añez, Luis M; Paris, Manuel et al. (2014) The convergence of personality disorder diagnoses across different methods among monolingual (Spanish-speaking only) Hispanic patients in substance use treatment. Personal Disord 5:172-7 |
| Thomas, Katherine M; Hopwood, Christopher J; Donnellan, M Brent et al. (2014) Personality heterogeneity in PTSD: distinct temperament and interpersonal typologies. Psychol Assess 26:23-34 |
| Boisseau, Christina L; Yen, Shirley; Markowitz, John C et al. (2013) Individuals with single versus multiple suicide attempts over 10years of prospective follow-up. Compr Psychiatry 54:238-42 |
| Hopwood, Christopher J; Morey, Leslie C; Donnellan, M Brent et al. (2013) Ten-year rank-order stability of personality traits and disorders in a clinical sample. J Pers 81:335-44 |
| Grilo, Carlos M; Pagano, Maria E; Stout, Robert L et al. (2012) Stressful life events predict eating disorder relapse following remission: six-year prospective outcomes. Int J Eat Disord 45:185-92 |
| Suvak, Michael K; Sege, Christopher T; Sloan, Denise M et al. (2012) Emotional processing in borderline personality disorder. Personal Disord 3:273-82 |
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