Abstract

This proposal is driven by the hypothesis that regional specification of the forebrain is largely controlled by a hierarchy of genes encoding transcriptional regulators. A large portion of the proposal depends on gene knockout technology which will be used to inactivate the Dlx-1 and Dlx-2 genes, both individually and simultaneously. The phenotype of mice that are heterozygous and homozygous for the mutations will be analyzed histologically and biochemically.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
1R01MH051561-01A1
Application #
2250815
Study Section
Molecular, Cellular, and Developmental Neurobiology Review Committee (MCDN)
Project Start
1994-09-30
Project End
1997-08-31
Budget Start
1994-09-30
Budget End
1995-08-31
Support Year
1
Fiscal Year
1994
Total Cost
Indirect Cost

  Institution

Name
University of California San Francisco
Department
Type
Schools of Medicine
DUNS #
073133571
City
San Francisco
State
CA
Country
United States
Zip Code
94143

  Publications

Flames, Nuria; Long, Jason E; Garratt, Alistair N et al. (2004) Short- and long-range attraction of cortical GABAergic interneurons by neuregulin-1. Neuron 44:251-61
Marin, Oscar; Rubenstein, John L R (2003) Cell migration in the forebrain. Annu Rev Neurosci 26:441-83
Marin, Oscar; Plump, Andrew S; Flames, Nuria et al. (2003) Directional guidance of interneuron migration to the cerebral cortex relies on subcortical Slit1/2-independent repulsion and cortical attraction. Development 130:1889-901
Andrews, Gracie L; Yun, Kyuson; Rubenstein, John L R et al. (2003) Dlx transcription factors regulate differentiation of dopaminergic neurons of the ventral thalamus. Mol Cell Neurosci 23:107-20
Garel, Sonia; Huffman, Kelly J; Rubenstein, John L R (2003) Molecular regionalization of the neocortex is disrupted in Fgf8 hypomorphic mutants. Development 130:1903-14
Long, Jason E; Garel, Sonia; Depew, Michael J et al. (2003) DLX5 regulates development of peripheral and central components of the olfactory system. J Neurosci 23:568-78
Yun, Kyuson; Fischman, Seth; Johnson, Jane et al. (2002) Modulation of the notch signaling by Mash1 and Dlx1/2 regulates sequential specification and differentiation of progenitor cell types in the subcortical telencephalon. Development 129:5029-40
Anderson, Stewart A; Kaznowski, Christine E; Horn, Carrie et al. (2002) Distinct origins of neocortical projection neurons and interneurons in vivo. Cereb Cortex 12:702-9
Bagri, Anil; Marin, Oscar; Plump, Andrew S et al. (2002) Slit proteins prevent midline crossing and determine the dorsoventral position of major axonal pathways in the mammalian forebrain. Neuron 33:233-48
Marin, Oscar; Baker, Joshua; Puelles, Luis et al. (2002) Patterning of the basal telencephalon and hypothalamus is essential for guidance of cortical projections. Development 129:761-73

Showing the most recent 10 out of 30 publications