EXCEED THE SPACE PROVIDED. _^ I | Recent works point to the critical role of inhibitory interneurons in the regulation of the complex interactions of principal cells, including population oscillations, plasticity, epileptic! synchronization, hormonal effects and cortical development. In contrast to principal cells, a] very large number of classes of interneurons have been revealed by various laboratories, with different properties and hypothesized functions. However, no consensus has yet emerged for a functionally oriented classification scheme. A major goal of our project is to reveal the relationship between the physiological function of various interneuron groups in hippocampal network patterns and their biochemical, afferent and target properties. We propose that this combined approach will allow to bridge works performed in vivo and in vitro and will facilitate communication of knowledge at the various levels. A corollary of this project is to provide a n framework for the roles of interneuron classes in population bursts. The second goal is to understand the nature of interactions between hippocampal interneuron networks and thej medial septum in the generation of theta oscillation, a population pattern implicated in various cognitive functions. Finally, we will examine the plastic properties of interneurons. This issue is important because increasing synaptic efficacy between individual pyramidal cells and target interneurons may allow for changing the afferent accessibility of active principal cells. To achieve these goals, we will use intracellular labeling in vivo and in vitro and compare physiological properties with the morphological and biochemical features of the labeled cells. Recordings will be made from principal cell-interneuron pairs both in behaving animals and brain slices to examine synaptic plasticity. The findings will reveal a) the anatomical identity of physiologically distinct subclasses of interneurons, b) the role of interneurons in theta oscillation and c) behavior-dependence and modifiability of synaptic communication between principal cells and interneurons. Such knowledge is essential for understanding the consequences of interneuronal damage in disease, such as epilepsy and schizophrenia. PERFORMANCE SITE ========================================Section End===========================================
| Buzsáki, György; Tingley, David (2018) Space and Time: The Hippocampus as a Sequence Generator. Trends Cogn Sci 22:853-869 |
| Oliva, Azahara; Fernández-Ruiz, Antonio; Fermino de Oliveira, Eliezyer et al. (2018) Origin of Gamma Frequency Power during Hippocampal Sharp-Wave Ripples. Cell Rep 25:1693-1700.e4 |
| Watson, Brendon O; Ding, Mingxin; Buzsáki, György (2018) Temporal coupling of field potentials and action potentials in the neocortex. Eur J Neurosci 48:2482-2497 |
| Lisman, John; Buzsáki, György; Eichenbaum, Howard et al. (2017) Viewpoints: how the hippocampus contributes to memory, navigation and cognition. Nat Neurosci 20:1434-1447 |
| English, Daniel Fine; McKenzie, Sam; Evans, Talfan et al. (2017) Pyramidal Cell-Interneuron Circuit Architecture and Dynamics in Hippocampal Networks. Neuron 96:505-520.e7 |
| Levenstein, Daniel; Watson, Brendon O; Rinzel, John et al. (2017) Sleep regulation of the distribution of cortical firing rates. Curr Opin Neurobiol 44:34-42 |
| Fernández-Ruiz, Antonio; Oliva, Azahara; Nagy, Gerg? A et al. (2017) Entorhinal-CA3 Dual-Input Control of Spike Timing in the Hippocampus by Theta-Gamma Coupling. Neuron 93:1213-1226.e5 |
| Khodagholy, Dion; Gelinas, Jennifer N; Buzsáki, György (2017) Learning-enhanced coupling between ripple oscillations in association cortices and hippocampus. Science 358:369-372 |
| Roux, Lisa; Hu, Bo; Eichler, Ronny et al. (2017) Sharp wave ripples during learning stabilize the hippocampal spatial map. Nat Neurosci 20:845-853 |
| Peyrache, Adrien; Schieferstein, Natalie; Buzsáki, Gyorgy (2017) Transformation of the head-direction signal into a spatial code. Nat Commun 8:1752 |
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