A large data set of high-resolution coregistered PET/MRI images will be used to develop anatomical and image-processing methods to study the basal forebrain. Seventy rigorously screened healthy adults (5 men and 5 women in each decade from ages 20-90) were imaged while performing a serial verbal learning task. Thirty additional individuals will be imaged to increase statistical power. Scans were obtained with a GE 2048 head-dedicated scanner (4.5-mm resolution in plane, 2.5-3.5M counts) using 18F-deoxyglucose as the tracer. Coronal MRI images (1.2mm thick slices) were coregistered to the PET images. The investigator will focus on the striatum, pallidum and substantia innominata, with special attention to the ventral striatum (nucleus accumbens, striatal bridges into the substantia innominata) and ventral pallidum because they have been less studied (relative to the dorsal caudate and putamen) with MRI in man. A new 3D landmark-morphing method, thin-plate splines, will align and size all images to the same coordinates. The investigator will develop an atlas of basal forebrain anatomical landmarks and variance images for aligning subjects to uniform coordinates. He will test the hypothesis of greater age-related shrinkage and metabolic decrease in areas linked to motor cortex (posterior and dorsal putamen and globus pallidus) than areas linked to the limbic system (e.g., ventral striatum and pallidum). He will extend current correlational methods for understanding the topography of frontal-basal forebrain connectivity and evaluate the similarities between known nonhuman primate topography and human metabolic correlational pattern. Reciprocal compensatory size relationships between basal forebrain structures in the dorsal striatal (putamen to globus pallidus) and ventral (nucleus accumbens to ventral pallidum) systems will be explored to test the hypothesis that individuals with smaller striatal areas will show greater size or functional activity in the structures to which these areas send inhibitory projections. Lastly, the investigator will test realistic phantoms of the basal forebrain to provide accurate empirical measures of PET resolution and examine coronal postmortem cresyl violet and Weigert-stained brain slices to develop coronal slice location coordinates and assess their variation.
| Balevich, Emily C; Haznedar, M Mehmet; Wang, Eugene et al. (2015) Corpus callosum size and diffusion tensor anisotropy in adolescents and adults with schizophrenia. Psychiatry Res 231:244-51 |
| Mitelman, Serge A; Canfield, Emily L; Brickman, Adam M et al. (2010) Progressive ventricular expansion in chronic poor-outcome schizophrenia. Cogn Behav Neurol 23:85-8 |
| Hazlett, Erin A; Byne, William; Brickman, Adam M et al. (2010) Effects of sex and normal aging on regional brain activation during verbal memory performance. Neurobiol Aging 31:826-38 |
| Mitelman, Serge A; Canfield, Emily L; Chu, King-Wai et al. (2009) Poor outcome in chronic schizophrenia is associated with progressive loss of volume of the putamen. Schizophr Res 113:241-5 |
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| Hazlett, Erin A; Buchsbaum, Monte S; Haznedar, M Mehmet et al. (2008) Cortical gray and white matter volume in unmedicated schizotypal and schizophrenia patients. Schizophr Res 101:111-23 |
| Schneiderman, Jason S; Buchsbaum, Monte S; Haznedar, M Mehmet et al. (2007) Diffusion tensor anisotropy in adolescents and adults. Neuropsychobiology 55:96-111 |
| Buchsbaum, Monte S; Haznedar, M Mehmet; Aronowitz, Jonathan et al. (2007) FDG-PET in never-previously medicated psychotic adolescents treated with olanzapine or haloperidol. Schizophr Res 94:293-305 |
| Mitelman, Serge A; Torosjan, Yuliya; Newmark, Randall E et al. (2007) Internal capsule, corpus callosum and long associative fibers in good and poor outcome schizophrenia: a diffusion tensor imaging survey. Schizophr Res 92:211-24 |
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