This is a FIRST award proposal. The proposed project examines 6-13 year-old children of schizophrenic parents using smooth pursuit eye movements (SPEM). Two critical missing pieces of data in research on the development of schizophrenia are: (a) Whether or not persons who are at increased genetic risk to later develop schizophrenia have abnormal SPEM in childhood, and (b) is abnormal SPEM in childhood associated with the presentation of symptom, behavioral, or poor peer problems. By studying children who are at increased risk to later develop schizophrenia, but who have not yet developed the clinical disorder, it is possible to assess whether SPEM abnormalities occur only in adulthood directly tired to presentation of clinical schizophrenia or whether SPEM abnormalities are predetermined, presenting years prior to onset of the full clinical syndrome (aim # 2 of this proposal). Previous efforts to explore this question have been hampered by a failure to understand SPEM within the confines of normal development. Understanding the normal developmental course of SPEM performance (aim #1 of this proposal) is critical to assessing t- risk/normal differences. It is important to address whether clinical difficulties presented by the at-risk group are associated with the SPEM abnormalities. Specifically, within the at-risk group, are those children who exhibit SPEM abnormalities more likely to show symptom, behavioral, or peer adjustment abnormalities than those at- risk children who have normal SPEM (aim #3 of this proposal). The relationship between SPEM and clinical presentation may be stable across the schoolage years, may change as a result of development, or may vary secondary to environmental or other effects. SPEM testing, behavioral and symptom evaluations, and peer adjustment assessments will be repeated 2 years after entry into the study. This will help differentiate these possibilities (aim #4 of this proposal).

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH056539-04
Application #
6186416
Study Section
Child Psychopathology and Treatment Review Committee (CPT)
Program Officer
Stoff, David M
Project Start
1997-07-01
Project End
2002-06-30
Budget Start
2000-07-01
Budget End
2001-06-30
Support Year
4
Fiscal Year
2000
Total Cost
$103,433
Indirect Cost
Name
University of Colorado Denver
Department
Psychiatry
Type
Schools of Medicine
DUNS #
065391526
City
Aurora
State
CO
Country
United States
Zip Code
80045
Hutchison, Amanda K; Hunter, Sharon K; Wagner, Brandie D et al. (2017) Diminished Infant P50 Sensory Gating Predicts Increased 40-Month-Old Attention, Anxiety/Depression, and Externalizing Symptoms. J Atten Disord 21:209-218
Ross, Randal G; Hunter, Sharon K; Hoffman, M Camille et al. (2016) Perinatal Phosphatidylcholine Supplementation and Early Childhood Behavior Problems: Evidence for CHRNA7 Moderation. Am J Psychiatry 173:509-16
Hunter, Sharon K; Gillow, Sabreena J; Ross, Randal G (2015) Stability of P50 auditory sensory gating during sleep from infancy to 4 years of age. Brain Cogn 94:4-9
Brodsky, Kimberly; Willcutt, Erik G; Davalos, Deana B et al. (2014) Neuropsychological functioning in childhood-onset psychosis and attention-deficit/hyperactivity disorder. J Child Psychol Psychiatry 55:811-8
Pellegrino, Laurel; Ross, Randal G; Hunter, Sharon K (2013) In Six-month-old Infants, Prenatal Exposure to Maternal Anxiety is Associated with Less Developed Smooth Pursuit Eye Movements: An Initial Study. Int Neuropsychiatr Dis J 1:89-103
Ross, Anne Spencer; Hunter, Sharon Kay; Groth, Mark A et al. (2013) P50 sensory gating in infants. J Vis Exp :50065
D'Anna-Hernandez, Kimberly L; Zerbe, Gary O; Hunter, Sharon K et al. (2013) Paternal psychopathology and maternal depressive symptom trajectory during the first year postpartum. Ment Illn 5:e1
Ross, Randal G; Hunter, Sharon K; McCarthy, Lizbeth et al. (2013) Perinatal choline effects on neonatal pathophysiology related to later schizophrenia risk. Am J Psychiatry 170:290-8
Reidy, Rosemary E; Ross, Randal G; Hunter, Sharon K (2013) Theory of Mind Development is Impaired in 4-year-old Children with Prenatal Exposure to Maternal Tobacco Smoking. Int Neuropsychiatr Dis J 1:24-34
Sparks, Tierney A; Hunter, Sharon K; Backman, Toni L et al. (2012) Maternal parenting stress and mothers' reports of their infants' mastery motivation. Infant Behav Dev 35:167-73

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