This project will use anuran amphibians as a model system to investigate the interaction of vertebrate communication behavior and hormonal control systems. Behavioral manipulations will test the hypothesis that repeated exposure to conspecific communication signals increases plasma sex steroid levels and changes the anatomical characteristics of three neurochemical systems in brain thought to be involved in hormonal regulation and reproductive control: the gonadotropin releasing hormone (GnRH) centers in the medical septal area and preoptic area expressing the mammalian LHRH form of this peptide, the tegmental GnRH center expressing the chicken II form of GnRH, and the tyrosine hydroxylase (TH) populations in the basal forebrain. Behavioral and hormonal manipulations will then test between two competing hypotheses: that any CNS changes observed are due to feedback from sex steroids released by exposure to conspecific calls vs. that CNS changes are directly due to sensory stimulation of these areas. In addition, neuroanatomical tracing experiments and immunohistochemistry will determine the connections of the medial septal LHRH areas and the tegmental chicken II GnRH area to determine which GnRH populations send efferents to the median eminence and neurohypophysis and hence may control sex steroid secretion from the gonads. Finally, sensory inputs to the medial septal area LHRH and tegmental chicken II GnRH centers will be examined to test the hypothesis that they, like the preoptic area and ventral hypothalamus centers previously examined, receive auditory input (conveying formation about communication signals) in a convergent pattern from the thalamus and isthmal tegmentum. The anatomical results will be related to the behavioral results to test the hypotheses: that both LHRH and chicken II GnRH neurons contribute to neurosecretory functions, and hence, the control of sex steroid secretion; that both forms are equally influenced by the reception of conspecific calls; and that both neurosecretory and non-neurosecretory subpopulations of each form, if such subdivisions exist, are equally influenced by the reception of conspecific calls. The project will enhance the understanding of sensory-endocrine interactions that are fundamental to a variety of natural behaviors with clinical significance, including reproduction and stress.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH057066-03
Application #
6165179
Study Section
Psychobiology, Behavior, and Neuroscience Review Committee (PBN)
Project Start
1998-03-10
Project End
2002-02-28
Budget Start
2000-04-25
Budget End
2001-02-28
Support Year
3
Fiscal Year
2000
Total Cost
$118,239
Indirect Cost
Name
University of Texas Austin
Department
Psychology
Type
Schools of Arts and Sciences
DUNS #
City
Austin
State
TX
Country
United States
Zip Code
78712
Almli, Lynn M; Wilczynski, Walter (2012) Socially modulated cell proliferation is independent of gonadal steroid hormones in the brain of the adult green treefrog (Hyla cinerea). Brain Behav Evol 79:170-80
Lutterschmidt, Deborah I; Wilczynski, Walter (2012) Sexually dimorphic effects of melatonin on brain arginine vasotocin immunoreactivity in green treefrogs (Hyla cinerea). Brain Behav Evol 80:222-32
Wilczynski, Walter; Lynch, Kathleen S (2011) Female sexual arousal in amphibians. Horm Behav 59:630-6
Wilczynski, Walter; Ryan, Michael J (2010) The behavioral neuroscience of anuran social signal processing. Curr Opin Neurobiol 20:754-63
O'Bryant, Erin L; Wilczynski, Walter (2010) Changes in plasma testosterone levels and brain AVT cell number during the breeding season in the green treefrog. Brain Behav Evol 75:271-81
Almli, Lynn M; Wilczynski, Walter (2009) Sex-specific modulation of cell proliferation by socially relevant stimuli in the adult green treefrog brain (Hyla cinerea). Brain Behav Evol 74:143-54
Dunham, Leslie A; Lutterschmidt, Deborah I; Wilczynski, Walter (2009) Kisspeptin-like immunoreactive neuron distribution in the green anole (Anolis carolinensis). Brain Behav Evol 73:129-37
Miranda, Jason A; Wilczynski, Walter (2009) Sex differences and androgen influences on midbrain auditory thresholds in the green treefrog, Hyla cinerea. Hear Res 252:79-88
Miranda, Jason A; Wilczynski, Walter (2009) Female reproductive state influences the auditory midbrain response. J Comp Physiol A Neuroethol Sens Neural Behav Physiol 195:341-9
Lynch, Kathleen S; Wilczynski, Walter (2008) Reproductive hormones modify reception of species-typical communication signals in a female anuran. Brain Behav Evol 71:143-50

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