Abstract

This application is to complete data collection and to conduct statistical analyses for the ongoing study """"""""Family Psychopathology in Child Bipolarity"""""""".
The aim of this project is to perform direct interviews of the first degree relatives of three groups of probands (total N=263) who are participants in the ongoing parallel study """"""""Phenomenology and Course of Pediatric Bipolar Disorder"""""""". Proband groups are: (1) 89 probands with a prepubertal and early adolescent bipolar disorder phenotype (PEA-BP). (2) 80 probands with attention-deficit hyperactivity disorder (ADHD) (hyperactive or combined types). (3) 94 probands who are normal community controls (CC). Merikangas et al (1989) criteria were used to design this family study, including that there were blind raters (no knowledge of the proband's group), rigorous assessment of the probands, longitudinal validation of the phenotype, no exclusions for psychopathology in the first degree relatives and control for specificity (ADHD control group). Ongoing data analysis supports the main study hypotheses. Specifically, there is significantly higher familial aggregation of bipolar disorders among the relatives of the PEA-BP compared to the ADHD and CC groups. Also, there is far greater familial aggregation of bipolar disorders among the relatives of the PEA-BP group compared to relatives of adult bipolar probands reported in the literature. Rates of mood disorders among the relatives of the CC group are similar to those reported in epidemiological samples, which provides reliability of the study methods. Validation of PEA-BP has been shown by reliable assessment, six-month stability, and one and two year diagnostic outcome. Support of the family study hypotheses will provide additional, important validation of the existence of prepubertal and early adolescent mania. Establishing high familial aggregation of bipolar disorders in relatives of PEA-BP probands will provide the basis for future genetic and genetic-environment interaction studies.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH057451-06
Application #
6788089
Study Section
Biobehavioral and Behavioral Processes 3 (BBBP)
Program Officer
James, Regina Smith
Project Start
1999-02-01
Project End
2005-07-31
Budget Start
2004-08-01
Budget End
2005-07-31
Support Year
6
Fiscal Year
2004
Total Cost
$250,562
Indirect Cost

  Institution

Name
Washington University
Department
Psychiatry
Type
Schools of Medicine
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130

  Publications

Tandon, Mini; Tillman, Rebecca; Agrawal, Arpana et al. (2016) Trajectories of ADHD severity over 10 years from childhood into adulthood. Atten Defic Hyperact Disord 8:121-30
Gallitano, Amelia L; Tillman, Rebecca; Dinu, Valentin et al. (2012) Family-based association study of early growth response gene 3 with child bipolar I disorder. J Affect Disord 138:387-96
Geller, Barbara; Harms, Michael P; Wang, Lei et al. (2009) Effects of age, sex, and independent life events on amygdala and nucleus accumbens volumes in child bipolar I disorder. Biol Psychiatry 65:432-7
Geller, Barbara; Tillman, Rebecca; Bolhofner, Kristine et al. (2008) Child bipolar I disorder: prospective continuity with adult bipolar I disorder;characteristics of second and third episodes;predictors of 8-year outcome. Arch Gen Psychiatry 65:1125-33
Geller, Barbara; Tillman, Rebecca; Bolhofner, Kristine et al. (2008) GAD1 single nucleotide polymorphism is in linkage disequilibrium with a child bipolar I disorder phenotype. J Child Adolesc Psychopharmacol 18:25-9
Insel, Beverly J; Schaefer, Catherine A; McKeague, Ian W et al. (2008) Maternal iron deficiency and the risk of schizophrenia in offspring. Arch Gen Psychiatry 65:1136-44
Geller, Barbara; Tillman, Rebecca; Bolhofner, Kristine et al. (2006) Controlled, blindly rated, direct-interview family study of a prepubertal and early-adolescent bipolar I disorder phenotype: morbid risk, age at onset, and comorbidity. Arch Gen Psychiatry 63:1130-8
Tillman, Rebecca; Geller, Barbara (2006) Controlled study of switching from attention-deficit/hyperactivity disorder to a prepubertal and early adolescent bipolar I disorder phenotype during 6-year prospective follow-up: rate, risk, and predictors. Dev Psychopathol 18:1037-53
Geller, Barbara; Tillman, Rebecca; Badner, Judith A et al. (2005) Are the arginine vasopressin V1a receptor microsatellites related to hypersexuality in children with a prepubertal and early adolescent bipolar disorder phenotype? Bipolar Disord 7:610-6
Geller, Barbara; Tillman, Rebecca (2005) Prepubertal and early adolescent bipolar I disorder: review of diagnostic validation by Robins and Guze criteria. J Clin Psychiatry 66 Suppl 7:21-8

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