Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH057833-02
Application #
6185834
Study Section
Special Emphasis Panel (ZRG1-BDCN-3 (01))
Program Officer
Meinecke, Douglas L
Project Start
1999-09-01
Project End
2002-08-31
Budget Start
2000-09-01
Budget End
2001-08-31
Support Year
2
Fiscal Year
2000
Total Cost
$280,165
Indirect Cost

  Institution

Name
Stanford University
Department
Psychiatry
Type
Schools of Medicine
DUNS #
800771545
City
Stanford
State
CA
Country
United States
Zip Code
94305

  Publications

Parvathy, Saravanapavan; Rajadas, Jayakumar; Ryan, Heather et al. (2009) Abeta peptide conformation determines uptake and interleukin-1alpha expression by primary microglial cells. Neurobiol Aging 30:1792-804
Selwood, Simon P; Parvathy, S; Cordell, Barbara et al. (2009) Gene expression profile of the PDAPP mouse model for Alzheimer's disease with and without Apolipoprotein E. Neurobiol Aging 30:574-90
Mitrasinovic, Olivera M; Grattan, Alicia; Robinson, Christopher C et al. (2005) Microglia overexpressing the macrophage colony-stimulating factor receptor are neuroprotective in a microglial-hippocampal organotypic coculture system. J Neurosci 25:4442-51
Mitrasinovic, Olivera M; Robinson, Christopher C; Tenen, Daniel G et al. (2004) Biolistic expression of the macrophage colony stimulating factor receptor in organotypic cultures induces an inflammatory response. J Neurosci Res 77:420-9
Mitrasinovic, Olivera M; Murphy Jr, Greer M (2003) Microglial overexpression of the M-CSF receptor augments phagocytosis of opsonized Abeta. Neurobiol Aging 24:807-15
Mitrasinovic, Olivera M; Murphy Jr, Greer M (2002) Accelerated phagocytosis of amyloid-beta by mouse and human microglia overexpressing the macrophage colony-stimulating factor receptor. J Biol Chem 277:29889-96
Vincent, Valerie A M; Selwood, Simon P; Murphy Jr, Greer M (2002) Proinflammatory effects of M-CSF and A beta in hippocampal organotypic cultures. Neurobiol Aging 23:349-62
Lue, L F; Rydel, R; Brigham, E F et al. (2001) Inflammatory repertoire of Alzheimer's disease and nondemented elderly microglia in vitro. Glia 35:72-9
Mitrasinovic, O M; Perez, G V; Zhao, F et al. (2001) Overexpression of macrophage colony-stimulating factor receptor on microglial cells induces an inflammatory response. J Biol Chem 276:30142-9
Murphy Jr, G M; Zhao, F; Yang, L et al. (2000) Expression of macrophage colony-stimulating factor receptor is increased in the AbetaPP(V717F) transgenic mouse model of Alzheimer's disease. Am J Pathol 157:895-904