Abstract

Obsessive-compulsive disorder (OCD) is a common psychiatric disorder with a lifetime prevalence of 2.5 percent. Family studies indicate that OCD and sub-clinical obsessive-compulsive symptoms are familial. About one third of cases have onset by age 15 years. Recent family studies of OCS suggest that an early onset is associated with increased familial risk. The long-term goal of this project is to improve our understanding of the etiology of OCD by identifying susceptibility loci involved in early-onset OCD and determining the expression of these loci. An initial collection of families with early-onset OCD will be expanded through ascertainment of an additional 120 families with early-onset probands in which there is an affected sibling or second-degree relative. DNA from family members will be genotyped with mapped microsatellite markers and amplified by multiplex PCR spaced about every 10 cM. Parametric and nonparametric linkage analyses will be performed. Once evidence for linkage between early-onset OCD and a genetic marker is found, more precise gene localization will be pursued.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH058376-03
Application #
6392352
Study Section
Genome Study Section (GNM)
Program Officer
Moldin, Steven Owen
Project Start
1999-08-15
Project End
2004-07-31
Budget Start
2001-08-01
Budget End
2004-07-31
Support Year
3
Fiscal Year
2001
Total Cost
$376,193
Indirect Cost

  Institution

Name
University of Michigan Ann Arbor
Department
Psychiatry
Type
Schools of Medicine
DUNS #
791277940
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109

  Publications

McGrath, Lauren M; Yu, Dongmei; Marshall, Christian et al. (2014) Copy number variation in obsessive-compulsive disorder and tourette syndrome: a cross-disorder study. J Am Acad Child Adolesc Psychiatry 53:910-9
Davis, Lea K; Yu, Dongmei; Keenan, Clare L et al. (2013) Partitioning the heritability of Tourette syndrome and obsessive compulsive disorder reveals differences in genetic architecture. PLoS Genet 9:e1003864
Stewart, S E; Mayerfeld, C; Arnold, P D et al. (2013) Meta-analysis of association between obsessive-compulsive disorder and the 3' region of neuronal glutamate transporter gene SLC1A1. Am J Med Genet B Neuropsychiatr Genet 162B:367-79
Veenstra-VanderWeele, Jeremy; Xu, Tim; Ruggiero, Alicia M et al. (2012) Functional studies and rare variant screening of SLC1A1/EAAC1 in males with obsessive-compulsive disorder. Psychiatr Genet 22:256-60
Mathews, Carol A; Badner, Judith A; Andresen, J Michael et al. (2012) Genome-wide linkage analysis of obsessive-compulsive disorder implicates chromosome 1p36. Biol Psychiatry 72:629-36
Hanna, Gregory L; Himle, Joseph A; Hanna, Barbara S et al. (2011) Major depressive disorder in a family study of obsessive-compulsive disorder with pediatric probands. Depress Anxiety 28:501-8
Hanna, Gregory L; Veenstra-Vanderweele, Jeremy; Cox, Nancy J et al. (2007) Evidence for a susceptibility locus on chromosome 10p15 in early-onset obsessive-compulsive disorder. Biol Psychiatry 62:856-62
Dickel, Diane E; Veenstra-VanderWeele, Jeremy; Bivens, Nancy Chiu et al. (2007) Association studies of serotonin system candidate genes in early-onset obsessive-compulsive disorder. Biol Psychiatry 61:322-9
Dickel, Diane E; Veenstra-VanderWeele, Jeremy; Cox, Nancy J et al. (2006) Association testing of the positional and functional candidate gene SLC1A1/EAAC1 in early-onset obsessive-compulsive disorder. Arch Gen Psychiatry 63:778-85
Hanna, Gregory L; Fischer, Daniel J; Chadha, Kristin R et al. (2005) Familial and sporadic subtypes of early-onset Obsessive-Compulsive disorder. Biol Psychiatry 57:895-900

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