Researchers have long agreed that it is more appropriate to view child and adolescent psychopathology as multi-dimensional than un-dimensional. Consequently, the field has a long tradition of attempting to use empirical methods to define the multiple dimensions of psychopathology. In spite of these efforts, however, there is still marked disagreement about the number and nature of dimensions of psychopathology in youths. This disagreement on the fundamental units of measurement seriously limits scientific progress in the study of etiology. The proposed study will use a combination of psychometric and behavior genetic methods to resolve disagreements about the basic dimensions of psychopathology in children and adolescents. Using data from a sample of twins, confirmatory factor analysis will be used to test the fit of alternative methods of the underlying structure of child and adolescent psychopathology derived from prior research and theory. The proposed study will go well beyond factor analysis, however, by validating the putative dimensions using both criterion validity and behavior genetic strategies. Two putative dimensions of psychopathology that do not show different patterns of association with external criterion variables would not be considered to be meaningfully distinct dimensions. Similarly, two putatively distinct dimensions that do not exhibit genetic and/or environmental influences would not be considered to be distinct dimensions. Potential development and gender differences in the dimensions of psychopathology will be evaluated using structural equation modeling.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH059111-05
Application #
6719008
Study Section
Child Psychopathology and Treatment Review Committee (CPT)
Program Officer
Bourdon, Karen H
Project Start
2000-03-05
Project End
2005-02-28
Budget Start
2004-03-01
Budget End
2005-02-28
Support Year
5
Fiscal Year
2004
Total Cost
$170,304
Indirect Cost
Name
National Opinion Research Center
Department
Type
DUNS #
069512291
City
Chicago
State
IL
Country
United States
Zip Code
60637
Lahey, Benjamin B; Zald, David H; Perkins, Scott F et al. (2018) Measuring the hierarchical general factor model of psychopathology in young adults. Int J Methods Psychiatr Res 27:
Waldman, Irwin D; Poore, Holly E; van Hulle, Carol et al. (2016) External validity of a hierarchical dimensional model of child and adolescent psychopathology: Tests using confirmatory factor analyses and multivariate behavior genetic analyses. J Abnorm Psychol 125:1053-1066
Burke, Jeffrey D; Boylan, Khrista; Rowe, Richard et al. (2014) Identifying the irritability dimension of ODD: Application of a modified bifactor model across five large community samples of children. J Abnorm Psychol 123:841-51
Tackett, Jennifer L; Lahey, Benjamin B; van Hulle, Carol et al. (2013) Common genetic influences on negative emotionality and a general psychopathology factor in childhood and adolescence. J Abnorm Psychol 122:1142-53
Davis, F Caroline; Knodt, Annchen R; Sporns, Olaf et al. (2013) Impulsivity and the modular organization of resting-state neural networks. Cereb Cortex 23:1444-52
Lahey, Benjamin B; McNealy, Kristin; Knodt, Annchen et al. (2012) Using confirmatory factor analysis to measure contemporaneous activation of defined neuronal networks in functional magnetic resonance imaging. Neuroimage 60:1982-91
Lahey, Benjamin B; Waldman, Irwin D (2012) Annual research review: phenotypic and causal structure of conduct disorder in the broader context of prevalent forms of psychopathology. J Child Psychol Psychiatry 53:536-57
Willcutt, Erik G; Nigg, Joel T; Pennington, Bruce F et al. (2012) Validity of DSM-IV attention deficit/hyperactivity disorder symptom dimensions and subtypes. J Abnorm Psychol 121:991-1010
Tackett, Jennifer L; Waldman, Irwin D; Van Hulle, Carol A et al. (2011) Shared genetic influences on negative emotionality and major depression/conduct disorder comorbidity. J Am Acad Child Adolesc Psychiatry 50:818-27
Lahey, Benjamin B; Van Hulle, Carol A; Singh, Amber L et al. (2011) Higher-order genetic and environmental structure of prevalent forms of child and adolescent psychopathology. Arch Gen Psychiatry 68:181-9

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