Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH059786-05
Application #
6615716
Study Section
Special Emphasis Panel (ZRG1-MDCN-2 (01))
Program Officer
Asanuma, Chiiko
Project Start
2000-05-20
Project End
2006-06-30
Budget Start
2003-05-01
Budget End
2006-06-30
Support Year
5
Fiscal Year
2003
Total Cost
$176,750
Indirect Cost
Name
University of Southern California
Department
Pharmacology
Type
Schools of Pharmacy
DUNS #
072933393
City
Los Angeles
State
CA
Country
United States
Zip Code
90089
Thomas, Stefani N; Yang, Austin J (2017) Mass Spectrometry Analysis of Lysine Posttranslational Modifications of Tau Protein from Alzheimer's Disease Brain. Methods Mol Biol 1523:161-177
Thomas, Stefani N; Funk, Kristen E; Wan, Yunhu et al. (2012) Dual modification of Alzheimer's disease PHF-tau protein by lysine methylation and ubiquitylation: a mass spectrometry approach. Acta Neuropathol 123:105-17
Thomas, Stefani N; Cripps, Diane; Yang, Austin J (2009) Proteomic analysis of protein phosphorylation and ubiquitination in Alzheimer's disease. Methods Mol Biol 566:109-21
Wan, Yunhu; Cripps, Diane; Thomas, Stefani et al. (2008) PhosphoScan: a probability-based method for phosphorylation site prediction using MS2/MS3 pair information. J Proteome Res 7:2803-11
Jaje, Jennifer; Wolcott, Holly N; Fadugba, Olajumoke et al. (2007) A flavin-dependent sulfhydryl oxidase in bovine milk. Biochemistry 46:13031-40
Tekirian, Tina L; Thomas, Stefani N; Yang, Austin (2007) Advancing signaling networks through proteomics. Expert Rev Proteomics 4:573-83
Lee, Yung-Kang; Thomas, Stefani N; Yang, Austin J et al. (2007) Doxorubicin down-regulates Kruppel-associated box domain-associated protein 1 sumoylation that relieves its transcription repression on p21WAF1/CIP1 in breast cancer MCF-7 cells. J Biol Chem 282:1595-606
Cripps, Diane; Thomas, Stefani N; Jeng, Young et al. (2006) Alzheimer disease-specific conformation of hyperphosphorylated paired helical filament-Tau is polyubiquitinated through Lys-48, Lys-11, and Lys-6 ubiquitin conjugation. J Biol Chem 281:10825-38
Soreghan, Brian A; Lu, Bing-Wen; Thomas, Stefani N et al. (2005) Using proteomics and network analysis to elucidate the consequences of synaptic protein oxidation in a PS1 + AbetaPP mouse model of Alzheimer's disease. J Alzheimers Dis 8:227-41
Thomas, Stefani N; Soreghan, Brian A; Nistor, Mihaela et al. (2005) Reduced neuronal expression of synaptic transmission modulator HNK-1/neural cell adhesion molecule as a potential consequence of amyloid beta-mediated oxidative stress: a proteomic approach. J Neurochem 92:705-17

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