Abstract

Thirteen percent of women experience depression during the first 12 months postpartum, which adversely impacts key aspects of maternal role functioning, i.e. maternal-infant interaction, infant caretaking, gratification in the maternal role, and use of preventive health services for the infant (immunizations and well-child visits). Antidepressants, such as Selective Serotonin Reuptake Inhibitors (SSRIs) improve depression symptoms and social functioning, but their impact upon maternal role functioning has not been determined. The purpose of this naturalistic, longitudinal supplement is to investigate the impact of SSRI treatment on maternal role functioning in women during the first postpartum year. In addition, we will determine if self-efficacy is higher in depressed women who are treated with SSRIs, and we will test if a model of self-efficacy, depression, SSRI use, and social support predicts maternal role functioning. The sample (N=270) will consist of 3 groups of postpartum women (depressed, treated with SSRIs; depressed and not treated; not depressed, not treated) who are evaluated 4 times. The study is a supplement to an NIMH funded investigation, Antidepressant Use During Pregnancy (5 R01 MH60335-02, Katherine L. Wisner, M.D. PI), which addresses the effects of both depression and drug intervention during pregnancy and the postpartum period on mothers and infants. In this study, data on many aspects of the psychosocial environment of pregnant and parenting women are collected in order to isolate developmental and other effects of prenatal drug exposure on the infant. Using much of the same data, the supplement enhances and extends research currently funded by NIMH to Dr. Wisner by asking an additional question that is a national health priority: Does treatment of PPD with antidepressants improve a woman's ability to fulfill key aspects of functioning in the maternal role? Results of the study will inform women and their health care providers on outcomes of the use of SSRIs in depressed, postpartum women, assisting with decision-making on the treatment of postpartum depression. ? ?

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
3R01MH060335-04S1
Application #
6680949
Study Section
Interventions Research Review Committee (ITV)
Program Officer
Rudorfer, Matthew V
Project Start
1999-08-15
Project End
2005-07-31
Budget Start
2003-08-26
Budget End
2004-07-31
Support Year
4
Fiscal Year
2003
Total Cost
$223,997
Indirect Cost

  Institution

Name
University of Pittsburgh
Department
Psychiatry
Type
Schools of Medicine
DUNS #
004514360
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213

  Publications

Di Florio, A; Putnam, K; Altemus, M et al. (2017) The impact of education, country, race and ethnicity on the self-report of postpartum depression using the Edinburgh Postnatal Depression Scale. Psychol Med 47:787-799
Putnam, Karen T; Wilcox, Marsha; Robertson-Blackmore, Emma et al. (2017) Clinical phenotypes of perinatal depression and time of symptom onset: analysis of data from an international consortium. Lancet Psychiatry 4:477-485
Eckhardt, Cara L; Eng, Heather; Dills, John L et al. (2016) The prevalence of rapid weight gain in infancy differs by the growth reference and age interval used for evaluation. Ann Hum Biol 43:85-90
Kim, Deborah R; Pinheiro, Emily; Luther, James F et al. (2016) Is third trimester serotonin reuptake inhibitor use associated with postpartum hemorrhage? J Psychiatr Res 73:79-85
Logsdon, M Cynthia; Mittelberg, Meghan; Jacob, Alexandra E et al. (2015) Maternal-Infant interaction in women with unipoloar and bipolar depression. Appl Nurs Res 28:381-3
Postpartum Depression: Action Towards Causes and Treatment (PACT) Consortium (2015) Heterogeneity of postpartum depression: a latent class analysis. Lancet Psychiatry 2:59-67
Santucci, Aimee K; Singer, Lynn T; Wisniewski, Stephen R et al. (2014) Impact of prenatal exposure to serotonin reuptake inhibitors or maternal major depressive disorder on infant developmental outcomes. J Clin Psychiatry 75:1088-95
Sit, Dorothy; Luther, James; Dills, John Louis Jesse et al. (2014) Abnormal screening for gestational diabetes, maternal mood disorder, and preterm birth. Bipolar Disord 16:308-17
Wisner, Katherine L; Bogen, Debra L; Sit, Dorothy et al. (2013) Does fetal exposure to SSRIs or maternal depression impact infant growth? Am J Psychiatry 170:485-93
Tomedi, Laura E; Chang, Chung-Chou H; Newby, P K et al. (2013) Pre-pregnancy obesity and maternal nutritional biomarker status during pregnancy: a factor analysis. Public Health Nutr 16:1414-8

Showing the most recent 10 out of 46 publications