Executive processes play a central role in cognition. Although executive processes are difficult to define, there is general agreement that they are metaprocesses and that they include the following: (a) attention to task-relevant processes and inhibition of irrelevant processes or responses, (b) task-management, which includes switching among two or more known tasks, and planning subtasks in the correct temporal or logical order to satisfy an overall goal, (c) coding of contextual source information about an event, and (d) monitoring the current state of one's actions. There is also general agreement that these executive processes are mediated in large part by mechanisms of the prefrontal cortex, that portion of frontal cortex anterior to the motor regions. When patients have damage to these prefrontal mechanisms, their executive processes suffer dramatically. The proposed research program makes use of behavioral and fMRI studies of the first two of these executive processes, attention/inhibition and task-management. The research focuses on these two because they are at the core of discussion of executive processes and because they share a reliance on selective attention. The proposed research has three major aims: The first is to determine whether there are commonalities and differences between these two executive processes in behavioral and neural signatures. The second goal is to study the executive process of inhibition in detail. For this goal, we propose studies that should determine: (a) what brain circuitry is involved in attentional and inhibitory control, (b) how overt behavior and underlying neural circuitry differ for different sorts of inhibition, (c) whether the overt behavior and underlying circuitry depend on the content of the materials involved, and (d) whether there are systematic individual difference in inhibition both behaviorally and in the neural circuits involved. The third goal is to study task-management in detail by studying task-switching, an important component of task-management. The empirical studies in service of this goal will try to determine: (a) the basic circuitry involved, (b) changes in behavior and circuitry with changes in what has to be switched, (c) changes in behavior and underlying circuitry with the content of what is switched, and (d) whether there are systematic individual differences in task-switching that are correlated with neural differences. In addition to the experimental work, the research continues to develop a computational model for these executive processes that derives from the empirical results. Patients with frontal lesions who have deficits on one or another executive process will be studied.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
1R01MH060655-01A1
Application #
6199663
Study Section
Special Emphasis Panel (ZRG1-BBBP-3 (02))
Program Officer
Kurtzman, Howard S
Project Start
2000-07-20
Project End
2005-06-30
Budget Start
2000-07-20
Budget End
2001-06-30
Support Year
1
Fiscal Year
2000
Total Cost
$364,595
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Psychology
Type
Schools of Arts and Sciences
DUNS #
791277940
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Cheng, Philip; Preston, Stephanie D; Jonides, John et al. (2015) Evidence against mood-congruent attentional bias in Major Depressive Disorder. Psychiatry Res 230:496-505
Thompson, Renee J; Kuppens, Peter; Mata, Jutta et al. (2015) Emotional clarity as a function of neuroticism and major depressive disorder. Emotion 15:615-24
Shen, Kelly; Miši?, Bratislav; Cipollini, Ben N et al. (2015) Stable long-range interhemispheric coordination is supported by direct anatomical projections. Proc Natl Acad Sci U S A 112:6473-8
Miši?, Bratislav; Fatima, Zainab; Askren, Mary K et al. (2014) The functional connectivity landscape of the human brain. PLoS One 9:e111007
Berman, Marc G; Misic, Bratislav; Buschkuehl, Martin et al. (2014) Does resting-state connectivity reflect depressive rumination? A tale of two analyses. Neuroimage 103:267-79
Foland-Ross, Lara C; Cooney, Rebecca E; Joormann, Jutta et al. (2014) Recalling happy memories in remitted depression: a neuroimaging investigation of the repair of sad mood. Cogn Affect Behav Neurosci 14:818-26
Nee, Derek Evan; Jonides, John (2013) Neural evidence for a 3-state model of visual short-term memory. Neuroimage 74:1-11
Craig, Kimberly S; Berman, Marc G; Jonides, John et al. (2013) Escaping the recent past: which stimulus dimensions influence proactive interference? Mem Cognit 41:650-70
Krpan, Katherine M; Kross, Ethan; Berman, Marc G et al. (2013) An everyday activity as a treatment for depression: the benefits of expressive writing for people diagnosed with major depressive disorder. J Affect Disord 150:1148-51
Foland-Ross, Lara C; Hamilton, J Paul; Joormann, Jutta et al. (2013) The neural basis of difficulties disengaging from negative irrelevant material in major depression. Psychol Sci 24:334-44

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