Abstract

The proposed study extends a longitudinal study of 784 persons who have been studied since 1975, and who will be an average age of 38 when assessed. The cohort was originally randomly sampled, and has remained closely representative of the age group and geographical area from which it was drawn. Uniquely, personality disorders (PDs) have been assessed since early adolescence, in conjunction with the Axis I disorders, and a broad range of risks and outcomes. In 27 publications (of 153 published or in press from the Children in the Community study) PDs have been shown to be related to a number of childhood risks and, in turn, to constitute unique risks for both subsequent Axis I disorders and for serious impairment in function.
The aims of the proposed research are to investigate: Changes in the prevalence and persistence of PD symptoms and disorders in mid-adulthood;Impact of previous and current PD on adult function, health, and health care;Prospective relationships between Axis I disorders and PD;Relationship of specific genetic differences to PD and related functioning;Environmental and experiential risk factors for PD and PD change;Risk/ gene interaction in predicting prevalence and course of PD;Impact of parental PD on parenting and on offspring.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH060911-09
Application #
7647991
Study Section
Adult Psychopathology and Disorders of Aging Study Section (APDA)
Program Officer
Breiling, James P
Project Start
1999-12-01
Project End
2011-06-30
Budget Start
2009-07-01
Budget End
2011-06-30
Support Year
9
Fiscal Year
2009
Total Cost
$499,341
Indirect Cost

  Institution

Name
New York State Psychiatric Institute
Department
Type
DUNS #
167204994
City
New York
State
NY
Country
United States
Zip Code
10032

  Publications

Chen, Lu; Huang, Yangxin; Kasen, Stephanie et al. (2015) Impact of Adolescent Personality Disorders on Obesity 17 Years Later. Psychosom Med 77:921-6
Maldonado, Lizmarie; Huang, Yangxin; Chen, Ren et al. (2013) Impact of early adolescent anxiety disorders on self-esteem development from adolescence to young adulthood. J Adolesc Health 53:287-92
Chen, Henian; Pine, Daniel S; Ernst, Monique et al. (2013) The MAOA gene predicts happiness in women. Prog Neuropsychopharmacol Biol Psychiatry 40:122-5
Camacho, Kathleen; Ehrensaft, Miriam K; Cohen, Patricia (2012) Exposure to intimate partner violence, peer relations, and risk for internalizing behaviors: a prospective longitudinal study. J Interpers Violence 27:125-41
Ehrensaft, Miriam K; Cohen, Patricia (2012) Contribution of family violence to the intergenerational transmission of externalizing behavior. Prev Sci 13:370-83
Anglin, Deidre M; Corcoran, Cheryl M; Brown, Alan S et al. (2012) Early cannabis use and schizotypal personality disorder symptoms from adolescence to middle adulthood. Schizophr Res 137:45-9
Ehrensaft, Miriam K; Knous-Westfall, Heather M; Cohen, Patricia (2011) Direct and indirect transmission of relationship functioning across generations. J Fam Psychol 25:942-52
Guan, Bingqing; Deng, Yunlong; Cohen, Patricia et al. (2011) Relative impact of Axis I mental disorders on quality of life among adults in the community. J Affect Disord 131:293-8
Kasen, Stephanie; Cohen, Patricia; Chen, Henian (2011) Developmental course of impulsivity and capability from age 10 to age 25 as related to trajectory of suicide attempt in a community cohort. Suicide Life Threat Behav 41:180-92
Johnson, Jeffrey G; Liu, Lydia; Cohen, Patricia (2011) Parenting behaviours associated with the development of adaptive and maladaptive offspring personality traits. Can J Psychiatry 56:447-56

Showing the most recent 10 out of 32 publications