The primary objective of this proposal is to study the neuroanatomical and biochemical substrates of Late-Onset Minor Depression presenting at general medical/geriatric clinical settings. We also propose to examine the role of medical comorbidity, together with structural abnormalities, in the pathophysiology of minor depression. In this study, we will focus exclusively on the frontal lobes and obtain volumetric estimates of its subregions together with quantitative estimates of high intensity lesion volume using magnetic resonance imaging (MRI). We will also examine biochemical measures such as N-Acetyl Aspartate, Choline and Creatine from the gray and white matter of the frontal lobes using magnetic resonance spectroscopy (MRS). The relationship between specific neuroanatomical measures and relevant clinical indicators of disease burden will be studies and their relative contributions to late onset minor depression ascertained.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH061567-03
Application #
6539105
Study Section
Special Emphasis Panel (ZRG1-BDCN-1 (03))
Program Officer
Meinecke, Douglas L
Project Start
2000-04-01
Project End
2005-03-31
Budget Start
2002-04-01
Budget End
2003-03-31
Support Year
3
Fiscal Year
2002
Total Cost
$423,804
Indirect Cost
Name
University of California Los Angeles
Department
Type
Schools of Medicine
DUNS #
119132785
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
Kumar, Anand; Ajilore, Olusola; Zhang, Aifeng et al. (2014) Cortical thinning in patients with late-life minor depression. Am J Geriatr Psychiatry 22:459-64
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Nguyen, Thanh Tan; Wong, Tien Y; Islam, F M Amirul et al. (2010) Evidence of early retinal microvascular changes in patients with type 2 diabetes and depression. Psychosom Med 72:535-8
Ajilore, Olusola; Narr, Katherine; Rosenthal, Jonah et al. (2010) Regional cortical gray matter thickness differences associated with type 2 diabetes and major depression. Psychiatry Res 184:63-70
Elderkin-Thompson, Virginia; Hellemann, Gerhard; Pham, Daniel et al. (2009) Prefrontal brain morphology and executive function in healthy and depressed elderly. Int J Geriatr Psychiatry 24:459-68
Haroon, Ebrahim; Watari, Kecia; Thomas, Albert et al. (2009) Prefrontal myo-inositol concentration and visuospatial functioning among diabetic depressed patients. Psychiatry Res 171:10-9
Ballmaier, Martina; Kumar, Anand; Elderkin-Thompson, Virginia et al. (2008) Mapping callosal morphology in early- and late-onset elderly depression: an index of distinct changes in cortical connectivity. Neuropsychopharmacology 33:1528-36
Ballmaier, Martina; Narr, Katherine L; Toga, Arthur W et al. (2008) Hippocampal morphology and distinguishing late-onset from early-onset elderly depression. Am J Psychiatry 165:229-37
Watari, Kecia; Elderkin-Thompson, Virginia; Ajilore, Olu et al. (2008) Neuroanatomical correlates of executive functioning in depressed adults with type 2 diabetes. J Clin Exp Neuropsychol 30:389-97
Elderkin-Thompson, Virginia; Ballmaier, Martina; Hellemann, Gerhard et al. (2008) Executive function and MRI prefrontal volumes among healthy older adults. Neuropsychology 22:626-37

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