Abstract

The proposed project will test the internal and external validity of DSM-IV attention- deficit/hyperactivity disorder in an ethnically diverse population that includes a large proportion of African American and Hispanic children. Parent and teacher ratings of ADHD will be obtained for a large community sample of children in the Denver metropolitan area. The proposed study will provide the first estimates of the prevalence of DSM-IV ADHD among African American and Hispanic children, as well as the prevalence of each of the three diagnostic subtypes of DSM-IV ADHD. Several competing explanations for ethnic differences in the prevalence of ADHD will be tested, including rater bias and response to prejudice. Exploratory and confirmatory factor analysis will be used to test if the internal structure of the diagnosis varies as a function of ethnicity. Demographic variables such as socioeconomics status, location of residence, exposure to environmental stressors, and rater ethnicity will be assessed to test if these variables account for differences in the ratings of children from different ethnic groups. Measures of functional impairment and comorbid psychopathology will be administered to test if children with ADHD from different ethnic groups exhibit differences in these domains. In order to assess the etiology of ADHD in African American children, more extensive assessments will be conducted with 200 probands with ADHD and 200 comparison probands selected from the overall African American sample. Parental ADHD will be assessed to test if ADHD is significantly familial in an African American population, and data will be obtained regarding difficulties during pregnancy or delivery to test if perinatal complications are associated with ADHD. DNA samples will be obtained from all probands, their parents, and the biological sibling closest in age to the proband. Case- control and sib-pair comparisons, and the transmission disequilibrium test will be used to conduct the first for genetic association between several theoretically plausible candidates genes and ADHD in an AA sample.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH062120-05
Application #
6789972
Study Section
Special Emphasis Panel (ZRG1-BBBP-6 (01))
Program Officer
Rumsey, Judith M
Project Start
2000-08-15
Project End
2006-07-31
Budget Start
2004-08-01
Budget End
2006-07-31
Support Year
5
Fiscal Year
2004
Total Cost
$257,250
Indirect Cost

  Institution

Name
University of Colorado at Boulder
Department
Genetics
Type
Other Domestic Higher Education
DUNS #
007431505
City
Boulder
State
CO
Country
United States
Zip Code
80309

  Publications

Brodsky, Kimberly; Willcutt, Erik G; Davalos, Deana B et al. (2014) Neuropsychological functioning in childhood-onset psychosis and attention-deficit/hyperactivity disorder. J Child Psychol Psychiatry 55:811-8
Polanczyk, Guilherme V; Willcutt, Erik G; Salum, Giovanni A et al. (2014) ADHD prevalence estimates across three decades: an updated systematic review and meta-regression analysis. Int J Epidemiol 43:434-42
Willcutt, Erik G; Chhabildas, Nomita; Kinnear, Mikaela et al. (2014) The internal and external validity of sluggish cognitive tempo and its relation with DSM-IV ADHD. J Abnorm Child Psychol 42:21-35
Willcutt, Erik G (2012) The prevalence of DSM-IV attention-deficit/hyperactivity disorder: a meta-analytic review. Neurotherapeutics 9:490-9
Willcutt, Erik G; Nigg, Joel T; Pennington, Bruce F et al. (2012) Validity of DSM-IV attention deficit/hyperactivity disorder symptom dimensions and subtypes. J Abnorm Psychol 121:991-1010
Willcutt, Erik G; Boada, Richard; Riddle, Margaret W et al. (2011) Colorado Learning Difficulties Questionnaire: validation of a parent-report screening measure. Psychol Assess 23:778-91
Bidwell, L Cinnamon; Willcutt, Erik G; McQueen, Matthew B et al. (2011) A family based association study of DRD4, DAT1, and 5HTT and continuous traits of attention-deficit hyperactivity disorder. Behav Genet 41:165-74
McGrath, Lauren M; Pennington, Bruce F; Shanahan, Michelle A et al. (2011) A multiple deficit model of reading disability and attention-deficit/hyperactivity disorder: searching for shared cognitive deficits. J Child Psychol Psychiatry 52:547-57
Willcutt, Erik G; Betjemann, Rebecca S; McGrath, Lauren M et al. (2010) Etiology and neuropsychology of comorbidity between RD and ADHD: the case for multiple-deficit models. Cortex 46:1345-61
Willcutt, Erik G; Pennington, Bruce F; Duncan, Laramie et al. (2010) Understanding the complex etiologies of developmental disorders: behavioral and molecular genetic approaches. J Dev Behav Pediatr 31:533-44

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