Sensory gating, the brain's ability to modulate its sensitivity to sensory input, is an important neural protective and regulatory function. Deficits of this function have been found in a number of psychiatric conditions and may contribute particularly to the development of psychotic symptoms. These deficits can be studied by recording the P50, a positive cerebral evoked potential (EP) component peaking about 50 milliseconds following auditory stimulation. However, the cerebral structures mediating sensory gating and generating the P50 are not well known. Therefore, the main goal of the current proposal is to identify cerebral structures contributing to sensory gating and generating the P50 EP component by recording intracranial EPs directly from the human cerebral cortex and the hippocampus. Approximately 160 patients with medically intractable epilepsy in whom the presurgical evaluation necessitates the implantation of intracranial electrodes will be included in the study. EPs will be recorded from intrahippocampal depth and subdural strip electrodes in different cerebral regions. These data will be accumulated to map sensory gating processes onto the human cerebral cortex and the limbic system. In particular, the data will allow the examination of our hypothesis that the temporo-parietal region plays an important part in mediating sensory gating. In addition, intracranial sensory gating indices will be related to subject's psychiatric symptomatology (based on widely used rating scales). These data will shed more light on this crucial function and will help further our understanding of the mechanisms that lead to the development of psychotic disorders.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH063476-05
Application #
7081325
Study Section
Special Emphasis Panel (ZRG1-BDCN-6 (01))
Program Officer
Glanzman, Dennis L
Project Start
2002-05-16
Project End
2008-09-30
Budget Start
2006-03-01
Budget End
2008-09-30
Support Year
5
Fiscal Year
2006
Total Cost
$281,965
Indirect Cost
Name
Wayne State University
Department
Psychiatry
Type
Schools of Medicine
DUNS #
001962224
City
Detroit
State
MI
Country
United States
Zip Code
48202
Boutros, Nash N; Gjini, Klevest; Eickhoff, Simon B et al. (2013) Mapping repetition suppression of the P50 evoked response to the human cerebral cortex. Clin Neurophysiol 124:675-85
Boutros, Nash N; Gjini, Klevest; Urbach, Horst et al. (2011) Mapping repetition suppression of the N100 evoked response to the human cerebral cortex. Biol Psychiatry 69:883-9
Gjini, Klevest; Burroughs, Scott; Boutros, Nash N (2011) Relevance of attention in auditory sensory gating paradigms in schizophrenia A pilot study. J Psychophysiol 25:60-66
Gjini, Klevest; Arfken, Cynthia; Boutros, Nash N (2010) Relationships between sensory ""gating out"" and sensory ""gating in"" of auditory evoked potentials in schizophrenia: a pilot study. Schizophr Res 121:139-45
Rosburg, Timm; Boutros, Nash N; Ford, Judith M (2008) Reduced auditory evoked potential component N100 in schizophrenia--a critical review. Psychiatry Res 161:259-74
Rosburg, Timm; Trautner, Peter; Ludowig, Eva et al. (2008) Sensory gating in epilepsy - effects of the lateralization of hippocampal sclerosis. Clin Neurophysiol 119:1310-9
Weiland, Barbara J; Boutros, Nash N; Moran, John M et al. (2008) Evidence for a frontal cortex role in both auditory and somatosensory habituation: a MEG study. Neuroimage 42:827-35
Cromwell, Howard C; Mears, Ryan P; Wan, Li et al. (2008) Sensory gating: a translational effort from basic to clinical science. Clin EEG Neurosci 39:69-72
Boutros, N N; Mears, R; Pflieger, M E et al. (2008) Sensory gating in the human hippocampal and rhinal regions: regional differences. Hippocampus 18:310-6
Kurthen, Martin; Trautner, Peter; Rosburg, Timm et al. (2007) Towards a functional topography of sensory gating areas: invasive P50 recording and electrical stimulation mapping in epilepsy surgery candidates. Psychiatry Res 155:121-33

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