This is a resubmission of a application developed in response to an RFA concerning studies of the comorbidity of depression with a disruptive behavior disorder (oppositional defiant disorder; ODD) in children and adolescents, a condition that is believed to be particularly resistant to treatment and a precursor to adolescent drug abuse. The first critique of the application led to revisions in data analytic procedures to allow for SEM analysis to examine the overall model more carefully. Incorporating recommendations from reviewers for this resubmission expands the model to incorporate a new variable (attention problems), improves certain measures, incorporates teacher observations, and reintroduces certain elements of the original application to examine subgroups of children with clinically significant levels of ODD and depression. Oppositional defiant disorder (ODD) is the most common psychiatric problem among young children; depression meeting DSM diagnostic criteria is uncommon in preschoolers, but depressive symptoms are not. In studies of depression and ODD among the entire age spectrum of childhood and adolescents, several family, maternal, and child characteristics, along with the mother-child interactional patterns have been identified as risk factors/correlates, with most characteristics seeming to be risk factors for both ODD and depression. While studies of the early origins of ODD exist, relatively few have examined onset of depressive symptoms in young children, and even fewer have examined the development of ODD/depression comorbidity. This proposed study will examine a model included family (conflict, stressors), maternal (depression), child (temperament, school academic competence, social skills problems, attentional problems), and interactional (mother-child interaction, temperament) variables that have received empirical support as precursors to the development of ODD and depression in a large (N=1615) group of children age 4-5 at study onset. Participants will be recruited from public schools and primary care pediatric practices and followed across 3 annual waves of data collection. Primarily using structured equation modeling techniques, overall model fit and the role of specific variables in he development of ODD, depression, and their comorbidity will be examined for both parent and teacher-rated outcomes; additional analyses will examine clinical subgroups.

National Institute of Health (NIH)
National Institute of Mental Health (NIMH)
Research Project (R01)
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Child Psychopathology and Developmental Disabilities Study Section (CPDD)
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Moscicki, Eve K
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Children's Memorial Hospital (Chicago)
United States
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Lavigne, John V; Bryant, Fred B; Hopkins, Joyce et al. (2017) Age 4 Predictors of Oppositional Defiant Disorder in Early Grammar School. J Clin Child Adolesc Psychol :1-15
Lavigne, John V; Gouze, Karen R; Hopkins, Joyce et al. (2016) A multidomain cascade model of early childhood risk factors associated with oppositional defiant disorder symptoms in a community sample of 6-year-olds. Dev Psychopathol 28:1547-1562
Lavigne, John V; Dahl, Katharine P; Gouze, Karen R et al. (2015) Multi-domain predictors of oppositional defiant disorder symptoms in preschool children: cross-informant differences. Child Psychiatry Hum Dev 46:308-19
Lavigne, John V; Hopkins, Joyce; Gouze, Karen R et al. (2015) Bidirectional influences of anxiety and depression in young children. J Abnorm Child Psychol 43:163-76
Lavigne, John V; Bryant, Fred B; Hopkins, Joyce et al. (2015) Dimensions of oppositional defiant disorder in young children: model comparisons, gender and longitudinal invariance. J Abnorm Child Psychol 43:423-39
Lavigne, John V; Gouze, Karen R; Bryant, Fred B et al. (2014) Dimensions of Oppositional Defiant Disorder in young children: heterotypic continuity with anxiety and depression. J Abnorm Child Psychol 42:937-51
Lavigne, John V; Herzing, Laura B K; Cook, Edwin H et al. (2013) Gene × environment effects of serotonin transporter, dopamine receptor D4, and monoamine oxidase A genes with contextual and parenting risk factors on symptoms of oppositional defiant disorder, anxiety, and depression in a community sample of 4-year-old c Dev Psychopathol 25:555-75
Hopkins, Joyce; Lavigne, John V; Gouze, Karen R et al. (2013) Multi-domain models of risk factors for depression and anxiety symptoms in preschoolers: evidence for common and specific factors. J Abnorm Child Psychol 41:705-22
Hopkins, Joyce; Gouze, Karen R; Lavigne, John V (2013) Direct and indirect effects of contextual factors, caregiver depression, and parenting on attachment security in preschoolers. Attach Hum Dev 15:155-73
Lavigne, John V; Gouze, Karen R; Hopkins, Joyce et al. (2012) A multi-domain model of risk factors for ODD symptoms in a community sample of 4-year-olds. J Abnorm Child Psychol 40:741-57

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