The main goal of this proposal is to test the assumptions made by computational models concerning the operation of specific functions assigned to the hippocampus by developing a set of behavioral paradigms and to examine subregional specificity of the hippocampus. The importance of examining differential contributions of the sub regions of the hippocampus is to understand information flow within the hippocampus, so that it will be possible to determine input-output functions of the hippocampus and understand the contribution that the hippocampus makes to the overall processing of mnemonic information and memory representation. More specifically, the first aim is to develop behavioral paradigms to examine pattern separation processes based on spatial, temporal, and response attributes, to determine whether the dorsal and ventral hippocampus play a role in each of these pattern separation processes, and if so, to analyze subregional specificity (DG, CA1 and CA3) and test predictions made by computational models.
The second aim i s to develop behavioral paradigms to examine the formation of pattern associations including object-place and odor-place associations that involve non-spatial and spatial associations, odor-object associations that involve non-spatial associations, and odor-delay-object associations that involves non-spatial and temporal information, to determine whether the dorsal and ventral hippocampus play a role in the formation of each of these pattern associations, and if so, to analyze subregional specificity (DG, CA1 and CA3) and test predictions made by computational models.
The third aim i s to develop behavioral paradigms to examine pattern completion for spatial and temporal information, to determine whether the dorsal and ventral hippocampus play a role in pattern completion for spatial and temporal information, and if so, to analyze subregional specificity (DG, CA1 and CA3) and test predictions made by computational models. It is hoped that this information will be useful in understanding the role of sub regions of the dorsal and ventral hippocampus in processing mnemonic information in humans. This is of special interest since chronic stress appears to produce damage in the CA3 region and hypoxic episodes appear to produce cell loss primarily in the CA1 region.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
1R01MH065314-01A1
Application #
6562625
Study Section
Integrative, Functional and Cognitive Neuroscience 8 (IFCN)
Program Officer
Anderson, Kathleen C
Project Start
2002-12-01
Project End
2006-11-30
Budget Start
2002-12-01
Budget End
2003-11-30
Support Year
1
Fiscal Year
2003
Total Cost
$187,240
Indirect Cost
Name
University of Utah
Department
Psychology
Type
Schools of Arts and Sciences
DUNS #
009095365
City
Salt Lake City
State
UT
Country
United States
Zip Code
84112
Kesner, Raymond P; Rolls, Edmund T (2015) A computational theory of hippocampal function, and tests of the theory: new developments. Neurosci Biobehav Rev 48:92-147
Morris, Andrea M; Curtis, Brian J; Churchwell, John C et al. (2013) Temporal associations for spatial events: the role of the dentate gyrus. Behav Brain Res 256:250-6
Morris, Andrea M; Weeden, Christy S; Churchwell, John C et al. (2013) The role of the dentate gyrus in the formation of contextual representations. Hippocampus 23:162-8
Morris, Andrea M; Churchwell, John C; Kesner, Raymond P et al. (2012) Selective lesions of the dentate gyrus produce disruptions in place learning for adjacent spatial locations. Neurobiol Learn Mem 97:326-31
Churchwell, John C; Kesner, Raymond P (2011) Hippocampal-prefrontal dynamics in spatial working memory: interactions and independent parallel processing. Behav Brain Res 225:389-95
Churchwell, John C; Morris, Andrea M; Musso, Nicholas D et al. (2010) Prefrontal and hippocampal contributions to encoding and retrieval of spatial memory. Neurobiol Learn Mem 93:415-21
Kesner, Raymond P; Warthen, Danielle K (2010) Implications of CA3 NMDA and opiate receptors for spatial pattern completion in rats. Hippocampus 20:550-7
Kesner, Raymond P; Goodrich-Hunsaker, Naomi J (2010) Developing an animal model of human amnesia: the role of the hippocampus. Neuropsychologia 48:2290-302
Hunsaker, Michael R; Tran, Giang T; Kesner, Raymond P (2009) A behavioral analysis of the role of CA3 and CA1 subcortical efferents during classical fear conditioning. Behav Neurosci 123:624-30
Kesner, Raymond P (2009) The posterior parietal cortex and long-term memory representation of spatial information. Neurobiol Learn Mem 91:197-206

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