This is a collaborative research effort of Northwestern University and the University of California, Los Angeles to evaluate common and specific risk factors for anxiety disorders and depression. Each site will work on a common protocol. We propose a prospective longitudinal study of 700 high school juniors, recruited in two cohorts over consecutive years at two high schools (Evanston and Santa Monica). Using a high-risk design, participants at high risk (according to Neuroticism cores) will be oversampled relative to medium and low risk groups. Their progression will be carefully tracked over the course of 8 to 10 assessments staggered over four to four and a half years of data collection. The participant sample will be geographically, ethnically, and socio-economically diverse. The proposal takes a comprehensive biopsychosocial approach to the conceptualization and measurement of risk factors, which include Neuroticism, depressogenic cognitive style, anxiety sensitivity, introversion and low positive affectivity, sociotropy and autonomy. Measures will include self report, parental report, as well as information processing tasks (modified Stroop, memory tasks), affective modulation of startle reactivity, and ambulatory cortisol assays. In addition, diathesis-stress interactions will be evaluated on the basis of contextual assessment of chronic and episodic life stress. Outcome will be measured in terms of symptoms and diagnosis of anxiety and depression. Various models of commonalities and specificities of risk and their interaction with stress will be tested using hierarchical logistic regression and structural equation modeling. The findings may further our conceptualization of emotional disorders and provide the platform for prevention research.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH065652-03
Application #
6750164
Study Section
Special Emphasis Panel (ZMH1-CRB-J (05))
Program Officer
Chavez, Mark
Project Start
2002-06-18
Project End
2007-03-31
Budget Start
2004-06-01
Budget End
2005-03-31
Support Year
3
Fiscal Year
2004
Total Cost
$371,250
Indirect Cost
Name
Northwestern University at Chicago
Department
Psychology
Type
Schools of Arts and Sciences
DUNS #
160079455
City
Evanston
State
IL
Country
United States
Zip Code
60201
Conway, Christopher C; Zinbarg, Richard E; Mineka, Susan et al. (2017) Core dimensions of anxiety and depression change independently during adolescence. J Abnorm Psychol 126:160-172
Wolitzky-Taylor, Kate; Sewart, Amy; Vrshek-Schallhorn, Suzanne et al. (2017) The Effects of Childhood and Adolescent Adversity on Substance Use Disorders and Poor Health in Early Adulthood. J Youth Adolesc 46:15-27
Gilbert, Kirsten; Mineka, Susan; Zinbarg, Richard E et al. (2017) Emotion Regulation Regulates More than Emotion: Associations of Momentary Emotion Regulation with Diurnal Cortisol in Current and Past Depression and Anxiety. Clin Psychol Sci 5:37-51
Conway, Christopher C; Craske, Michelle G; Zinbarg, Richard E et al. (2016) PATHOLOGICAL PERSONALITY TRAITS AND THE NATURALISTIC COURSE OF INTERNALIZING DISORDERS AMONG HIGH-RISK YOUNG ADULTS. Depress Anxiety 33:84-93
Tabak, Benjamin A; Vrshek-Schallhorn, Suzanne; Zinbarg, Richard E et al. (2016) Interaction of CD38 Variant and Chronic Interpersonal Stress Prospectively Predicts Social Anxiety and Depression Symptoms Over Six Years. Clin Psychol Sci 4:17-27
Kendall, Ashley D; Zinbarg, Richard E; Bobova, Lyuba et al. (2016) Measuring Positive Emotion With the Mood and Anxiety Symptom Questionnaire: Psychometric Properties of the Anhedonic Depression Scale. Assessment 23:86-95
Kendall, Ashley D; Zinbarg, Richard E; Mineka, Susan et al. (2015) Prospective associations of low positive emotionality with first onsets of depressive and anxiety disorders: Results from a 10-wave latent trait-state modeling study. J Abnorm Psychol 124:933-43
Hoyt, Lindsay T; Craske, Michelle G; Mineka, Susan et al. (2015) Positive and negative affect and arousal: cross-sectional and longitudinal associations with adolescent cortisol diurnal rhythms. Psychosom Med 77:392-401
Vrshek-Schallhorn, Suzanne; Stroud, Catherine B; Mineka, Susan et al. (2015) Chronic and episodic interpersonal stress as statistically unique predictors of depression in two samples of emerging adults. J Abnorm Psychol 124:918-32
Vrshek-Schallhorn, Suzanne; Stroud, Catherine B; Mineka, Susan et al. (2015) Additive genetic risk from five serotonin system polymorphisms interacts with interpersonal stress to predict depression. J Abnorm Psychol 124:776-90

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