We seek support to analyze existing data from the Oregon Adolescent Depression Project (OADP) to better understand the pathways into and out of major depressive disorder (MDD) and the processes that mediate and moderate risk during the peak incidence period of adolescence-young adulthood. The OADP is a multi-generational project that includes a study of the prevalence and risk factors for adolescent psychopathology in a large community sample; a longitudinal follow-up of participants into young adulthood; a family study of first-degree relatives; and a longitudinal study of their children. We seek to extend previous OADP grants by addressing four broad issues that integrate these components using state-of-the-art data analytic procedures: 1) Onset of MDD in adolescents and young adults. Having a depressed parent is a critical risk factor for MDD. We will examine the specificity of the parental MDD-offspring MDD association and factors that moderate risk for MDD in offspring of depressed parents; explore environmental and person characteristics that mediate the relation between parent and offspring MDD; and compare risk factors for first-onset of MDD in adolescence versus young adulthood. 2) Course of MDD in adolescents and young adults. Adolescent MDD has a variable course. We will explore whether parental MDD is a useful marker for divergent pathways out of MDD; determine whether risk factors for first onset versus recurrent MDD differ; identify predictors of cumulative depression over time; and explore whether adolescents and young adults are changed or """"""""scarred"""""""" by the experience of MDD. 3) Stress and depression. MDD is associated with elevated stress both before and after episodes. Using seven annual assessments of life events and depressive symptoms between adolescence and young adulthood, and latent growth curve and growth mixture modeling, we will examine reciprocal relationships between stress and depression; whether parental MDD and personal history of MDD moderate stress-depression relationships; and individual differences in stress trajectories. 4) Behavior problems in young children of depressed parents. The multigenerational structure of the OADP provides an opportunity to examine some of these issues in the children of the original OADP cohort. We will use latent growth curve modeling to identify distinct groups of developmental trajectories of psychopathology in offspring, and examine grandparental, parental, and familial predictors of these trajectories.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH066023-03
Application #
6782707
Study Section
Special Emphasis Panel (ZRG1-SSS-C (03))
Program Officer
Bourdon, Karen H
Project Start
2002-08-09
Project End
2006-07-31
Budget Start
2004-08-01
Budget End
2006-07-31
Support Year
3
Fiscal Year
2004
Total Cost
$228,750
Indirect Cost
Name
Oregon Research Institute
Department
Type
DUNS #
053615423
City
Eugene
State
OR
Country
United States
Zip Code
97403
Danzig, Allison P; Bufferd, Sara J; Dougherty, Lea R et al. (2013) Longitudinal associations between preschool psychopathology and school-age peer functioning. Child Psychiatry Hum Dev 44:621-32
Klein, Daniel N; Glenn, Catherine R; Kosty, Derek B et al. (2013) Predictors of first lifetime onset of major depressive disorder in young adulthood. J Abnorm Psychol 122:1-6
Olino, Thomas M; Shankman, Stewart A; Klein, Daniel N et al. (2012) Lifetime rates of psychopathology in single versus multiple diagnostic assessments: comparison in a community sample of probands and siblings. J Psychiatr Res 46:1217-22
Olino, Thomas M; Klein, Daniel N; Farmer, Richard F et al. (2012) Examination of the structure of psychopathology using latent class analysis. Compr Psychiatry 53:323-32
Olino, Thomas M; Klein, Daniel N; Lewinsohn, Peter M et al. (2010) Latent trajectory classes of depressive and anxiety disorders from adolescence to adulthood: descriptions of classes and associations with risk factors. Compr Psychiatry 51:224-35
Shankman, Stewart A; Lewinsohn, Peter M; Klein, Daniel N et al. (2009) Subthreshold conditions as precursors for full syndrome disorders: a 15-year longitudinal study of multiple diagnostic classes. J Child Psychol Psychiatry 50:1485-94
Klein, Daniel N; Shankman, Stewart A; Lewinsohn, Peter M et al. (2009) Subthreshold depressive disorder in adolescents: predictors of escalation to full-syndrome depressive disorders. J Am Acad Child Adolesc Psychiatry 48:703-10
Olino, Thomas M; Klein, Daniel N; Lewinsohn, Peter M et al. (2008) Longitudinal associations between depressive and anxiety disorders: a comparison of two trait models. Psychol Med 38:353-63
Olino, Thomas M; Pettit, Jeremy W; Klein, Daniel N et al. (2008) Influence of parental and grandparental major depressive disorder on behavior problems in early childhood: a three-generation study. J Am Acad Child Adolesc Psychiatry 47:53-60
Shankman, S A; Klein, D N; Lewinsohn, P M et al. (2008) Family study of subthreshold psychopathology in a community sample. Psychol Med 38:187-98

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