A longitudinal study of 400 adoptive and 200 nonadoptive families is proposed to address recent critiques of research aimed at identifying environmental influences on psychological adjustment. Specifically, we seek to confirm the existence of shared environmental influences on adolescent problem behavior, determine whether they are developmentally stable, and explicate the specific sibling and parent factors that underlie their effect. Participating families will consist of adolescent sibling pairs and parents who completed an extensive in-person mental health and psychological assessment three years prior to the proposed follow-up. The in-person follow-up assessment will focus on the siblings and their primary caregivers and closely parallel the intake assessment by including: 1) mental health, 2) substance use and abuse, 3) behavioral Jeviance, 4) family and sibling relations, 5) adoption-specific risk factors, 6) individual-level risk factors, 7) other environmental risk and protective factors, and 8) demographic factors. The focus of the data analysis will be on: 1) estimating the strength of shared environmental influences using standard behavioral genetic models, 2) determining whether parent characteristics are associated with adolescent outcome in adoptive families, where genetic mediation is controlled, 3) testing a developmental model of sibling effects based on the notion of """"""""legitimization"""""""", and 4) determining whether specific environmental factors potentiate individual-level risk factors. Our large, representative sample of adopted adolescents also gives us an unprecedented opportunity to rigorously explore the adjustment of adopted individuals who had been placed in infancy. In this regard, we are especially interested in the adjustment of adopted individuals relative to nonadopted individuals, the contribution of adoption-specific risk factors to adoptee adjustment, and the effect of age on adoptees' concerns about birth background and ethnic identification.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH066140-03
Application #
6834601
Study Section
Social Sciences, Nursing, Epidemiology and Methods 4 (SNEM)
Program Officer
Moscicki, Eve K
Project Start
2003-03-10
Project End
2007-12-31
Budget Start
2005-01-01
Budget End
2005-12-31
Support Year
3
Fiscal Year
2005
Total Cost
$673,477
Indirect Cost
Name
University of Minnesota Twin Cities
Department
Psychology
Type
Schools of Arts and Sciences
DUNS #
555917996
City
Minneapolis
State
MN
Country
United States
Zip Code
55455
Park, Jun Young; Wu, Chong; Basu, Saonli et al. (2018) Adaptive SNP-Set Association Testing in Generalized Linear Mixed Models with Application to Family Studies. Behav Genet 48:55-66
Lee, James J; McGue, Matt; Iacono, William G et al. (2018) The accuracy of LD Score regression as an estimator of confounding and genetic correlations in genome-wide association studies. Genet Epidemiol 42:783-795
Samek, Diana R; Goodman, Rebecca J; Riley, Lucy et al. (2018) The Developmental Unfolding of Sibling Influences on Alcohol Use over Time. J Youth Adolesc 47:349-368
Arbet, Jaron; McGue, Matt; Chatterjee, Snigdhansu et al. (2017) Resampling-based tests for Lasso in genome-wide association studies. BMC Genet 18:70
Sniekers, Suzanne; Stringer, Sven; Watanabe, Kyoko et al. (2017) Genome-wide association meta-analysis of 78,308 individuals identifies new loci and genes influencing human intelligence. Nat Genet 49:1107-1112
McGue, Matt; Rustichini, Aldo; Iacono, William G (2017) Cognitive, Noncognitive, and Family Background Contributions to College Attainment: A Behavioral Genetic Perspective. J Pers 85:65-78
Coombes, Brandon; Basu, Saonli; McGue, Matt (2017) A combination test for detection of gene-environment interaction in cohort studies. Genet Epidemiol 41:396-412
Lam, Max; Trampush, Joey W; Yu, Jin et al. (2017) Large-Scale Cognitive GWAS Meta-Analysis Reveals Tissue-Specific Neural Expression and Potential Nootropic Drug Targets. Cell Rep 21:2597-2613
Weiss, Alexander; Baselmans, Bart M L; Hofer, Edith et al. (2016) Personality Polygenes, Positive Affect, and Life Satisfaction. Twin Res Hum Genet 19:407-17
Durbin, C Emily; Hicks, Brian M; Blonigen, Daniel M et al. (2016) Personality trait change across late childhood to young adulthood: Evidence for nonlinearity and sex differences in change. Eur J Pers 30:31-44

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