This application proposes two related studies: A population-based epidemiologic study of obesity and depression among women and a longitudinal study of obesity treatment among two cohorts (one with comorbid obesity and depression, one with obesity only) identified by the epidemiologic study. Study 1 - Epidemiologic Study: A population-based sample of approximately 6000 women aged 40-65 will be complete structured telephone assessment of weight, nutrient intake, physical activity, depression, functional impairment, and disability. Women with Body Mass Index (BMI) >30 will be oversampled. Insurance claims data will be used to measure health care costs.
Aims of the epidemiologic study include: 1) Examine the association between obesity and depression among middle-aged women 2) Examine the specific contributions of obesity and depression to disability and health care costs. Study 2 - Treatment study: A cohort of approximately 100 women with obesity (BMI > 30) and no current depressive disorder will be enrolled in a 6-month state-of-the-art group weight loss treatment. Approximately 200 women with comorbid obesity and depression will be randomly assigned to either the identical weight loss treatment or to a combined cognitive-behavior group therapy program focused on both depression and weight loss.
Aims of the treatment study will include: 1) Examine the effect of depression on success in weight loss treatment by comparing weight loss, diet, and exercise in depressed and non-depressed women enrolled in the identical weight loss program 2) Examine the benefits of a combined weight loss/depression intervention above those of weight loss treatment alone by comparing weight loss, nutrient intake, physical activity, depressive symptoms, functional impairment and disability in the two groups of women with comorbid obesity and depression randomly assigned to the two different intervention programs

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH068127-04
Application #
6923931
Study Section
Special Emphasis Panel (ZRG1-SSS-N (01))
Program Officer
Muehrer, Peter R
Project Start
2002-09-20
Project End
2007-08-31
Budget Start
2005-09-01
Budget End
2006-08-31
Support Year
4
Fiscal Year
2005
Total Cost
$618,808
Indirect Cost
Name
Group Health Cooperative
Department
Type
DUNS #
078198520
City
Seattle
State
WA
Country
United States
Zip Code
98101
Arterburn, David; Westbrook, Emily O; Ludman, Evette J et al. (2012) Relationship between obesity, depression, and disability in middle-aged women. Obes Res Clin Pract 6:e175-262
Arterburn, David; Westbrook, Emily O; Ludman, Evette J et al. (2012) Relationship between Obesity, Depression, and Disability in Middle-Aged Women. Obes Res Clin Pract 6:e197-e206
Simon, Gregory E; Arterburn, David; Rohde, Paul et al. (2011) Obesity, depression, and health services costs among middle-aged women. J Gen Intern Med 26:1284-90
Linde, Jennifer A; Simon, Gregory E; Ludman, Evette J et al. (2011) A randomized controlled trial of behavioral weight loss treatment versus combined weight loss/depression treatment among women with comorbid obesity and depression. Ann Behav Med 41:119-30
Simon, Gregory E; Rohde, Paul; Ludman, Evette J et al. (2010) Is success in weight loss treatment contagious (do attendance and outcomes cluster within treatment groups)? Obes Res Clin Pract 4:e247-342
Ludman, Evette; Simon, Gregory E; Ichikawa, Laura E et al. (2010) Does depression reduce the effectiveness of behavioral weight loss treatment? Behav Med 35:126-34
Simon, Gregory E; Rohde, Paul; Ludman, Evette J et al. (2010) Association between change in depression and change in weight among women enrolled in weight loss treatment. Gen Hosp Psychiatry 32:583-9
Ludman, Evette J; Ichikawa, Laura E; Simon, Gregory E et al. (2010) Breast and cervical cancer screening specific effects of depression and obesity. Am J Prev Med 38:303-10
Simon, Gregory E; Rohde, Paul; Ludman, Evette J et al. (2010) IS SUCCESS IN WEIGHT LOSS TREATMENT CONTAGIOUS (DO ATTENDANCE AND OUTCOMES CLUSTER WITHIN TREATMENT GROUPS)? Obes Res Clin Pract 4:283-291
Simon, Gregory E; Arterburn, David E (2009) Does comorbid psychiatric disorder argue for or against surgical treatment of obesity? Gen Hosp Psychiatry 31:401-2

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