The proposed project, entitled """"""""Targeting Acute HIV,"""""""" involves the evaluation, optimization and extension of North Carolina's Screening and Tracing of Active Transmission Program (STAT). As presently implemented statewide, the STAT Program encompasses all publicly funded routine HIV counseling and testing in NC (n= 120,000 annually). STAT provides for detection of very early acute HIV infections in this population by using novel specimen pooling and HIV RNA detection methods in a central State Laboratory of Public Health. Cases of acute HIV identified by these methods trigger initiation of immediate confirmatory testing, network notification and partner screening by a special team of professional Disease Intervention Specialists. The STAT program is prospectively collecting extensive data on acute cases and their contacts, thereby providing a unique window on active HIV transmission taking place over a large geographic area. The proposed research described in this application capitalizes on these data in order to address significant gaps in our current understanding of HIV transmission and its prevention. We have assembled an experienced team of investigators in order to: 1. Evaluate the impact and performance of a large scale, primary care-based acute HIV screening and partner notification program; 2. Characterize acute HIV infection as it presents in NC's routine testing population, and develop diagnostic strategies for targeting primary care-based acute HIV screening; 3. Describe a population of HIV positive individuals who are either knowingly or unknowingly transmitting HIV in NC communities; and 4. Perform detailed cost effectiveness modeling in order to optimize acute HIV-centered efforts at HIV prevention.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
1R01MH068686-01
Application #
6678476
Study Section
Special Emphasis Panel (ZMH1-NRB-W (07))
Program Officer
Gordon, Christopher M
Project Start
2003-09-19
Project End
2008-06-30
Budget Start
2003-09-19
Budget End
2004-06-30
Support Year
1
Fiscal Year
2003
Total Cost
$327,532
Indirect Cost
Name
University of North Carolina Chapel Hill
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
608195277
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
Keating, Sheila M; Kassanjee, Reshma; Lebedeva, Mila et al. (2016) Performance of the Bio-Rad Geenius HIV1/2 Supplemental Assay in Detecting ""Recent"" HIV Infection and Calculating Population Incidence. J Acquir Immune Defic Syndr 73:581-588
Kuruc, JoAnn D; Cope, Anna B; Sampson, Lynne A et al. (2016) Ten Years of Screening and Testing for Acute HIV Infection in North Carolina. J Acquir Immune Defic Syndr 71:111-9
Sanders, Eduard J; Wahome, Elizabeth; Powers, Kimberly A et al. (2015) Targeted screening of at-risk adults for acute HIV-1 infection in sub-Saharan Africa. AIDS 29 Suppl 3:S221-30
Pilcher, Christopher D; Louie, Brian; Facente, Shelley et al. (2013) Performance of rapid point-of-care and laboratory tests for acute and established HIV infection in San Francisco. PLoS One 8:e80629
Hampton, Kristen H; Serre, Marc L; Gesink, Dionne C et al. (2011) Adjusting for sampling variability in sparse data: geostatistical approaches to disease mapping. Int J Health Geogr 10:54
Powers, Kimberly A; Ghani, Azra C; Miller, William C et al. (2011) The role of acute and early HIV infection in the spread of HIV and implications for transmission prevention strategies in Lilongwe, Malawi: a modelling study. Lancet 378:256-68
Powers, Kimberly A; Hoffman, Irving F; Ghani, Azra C et al. (2011) Sexual partnership patterns in malawi: implications for HIV/STI transmission. Sex Transm Dis 38:657-66
Bebell, Lisa M; Pilcher, Christopher D; Dorsey, Grant et al. (2010) Acute HIV-1 infection is highly prevalent in Ugandan adults with suspected malaria. AIDS 24:1945-52
Pilcher, Christopher D; Christopoulos, Katerina A; Golden, Matthew (2010) Public health rationale for rapid nucleic acid or p24 antigen tests for HIV. J Infect Dis 201 Suppl 1:S7-15
Hsiang, Michelle S; Lin, Michael; Dokomajilar, Christian et al. (2010) PCR-based pooling of dried blood spots for detection of malaria parasites: optimization and application to a cohort of Ugandan children. J Clin Microbiol 48:3539-43

Showing the most recent 10 out of 25 publications