Studies suggest that approximately 30-45% of HIV-infected people continue to engage in some unprotected sexual activities. The perception that HIV-infection is now """"""""manageable"""""""" appears to increase the likelihood that HIV-infected persons will practice risky sexual behaviors. However, many patients have difficulty managing their illness with medication and people who adhere less to ART engage in more risky sex than others. When patients do not take all of their ART, their viral load often increases and they can develop resistant virus. Viral load level is the primary predictor of HIV transmission. Thus, people who are less adherent are more likely to transmit virus that may be resistant. Therefore, interventions to reduce the risky sexual behavior of persons with HIV, particularly those who are viremic are critically needed to slow the spread of HIV infection. To date, little research has demonstrated interventions that successfully reduced the risky sexual behaviors of HIV-infected individuals. In earlier work, the researchers in this proposal developed a multi-component audiotape/workbook-enhanced motivational interviewing tool to help persons with HIV improve their ART adherence and then adapted it to increase safer sex practices. In a collaborative effort between behavioral researchers and clinical virologists at the UNC Schools of Medicine, Public Health, Social Work and Dentistry, based on expertise in developing administering Motivational Interviews to persons with HIV, these researchers propose to use a theory-driven, Motivational Interviewing-based tool to enhance the safer sexual practices in a two-arm, randomized, controlled trial. The trial will be conducted among 490 viremic, HIV-infected individuals at a large Infectious Diseases Clinic, collecting self-reported sexual behaviors and urine assays for sexually transmitted infections at 3, 6 and 9 months. The study will also assess the relationship between risky sexual behaviors and adherence among this group of patients. The long term goals of this project are to produce and test better methods to reduce the spread of HIV.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
1R01MH069989-01A2
Application #
7006225
Study Section
Special Emphasis Panel (ZRG1-AARR-A (08))
Program Officer
Grossman, Cynthia I
Project Start
2005-08-15
Project End
2009-07-31
Budget Start
2005-08-15
Budget End
2006-07-31
Support Year
1
Fiscal Year
2005
Total Cost
$650,435
Indirect Cost
Name
University of North Carolina Chapel Hill
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
608195277
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
Grodensky, Catherine; Golin, Carol; Parikh, Megha A et al. (2017) Does the quality of safetalk motivational interviewing counseling predict sexual behavior outcomes among people living with HIV? Patient Educ Couns 100:147-153
Long, D Leann; Preisser, John S; Herring, Amy H et al. (2015) A Marginalized Zero-inflated Poisson Regression Model with Random Effects. J R Stat Soc Ser C Appl Stat 64:815-830
Long, D Leann; Preisser, John S; Herring, Amy H et al. (2014) A marginalized zero-inflated Poisson regression model with overall exposure effects. Stat Med 33:5151-65
Przybyla, Sarahmona; Golin, Carol; Widman, Laura et al. (2014) Examining the role of serostatus disclosure on unprotected sex among people living with HIV. AIDS Patient Care STDS 28:677-84
Widman, Laura; Golin, Carol E; Noar, Seth M (2013) When do condom use intentions lead to actions? Examining the role of sexual communication on safer sexual behavior among people living with HIV. J Health Psychol 18:507-17
Przybyla, Sarahmona M; Golin, Carol E; Widman, Laura et al. (2013) Serostatus disclosure to sexual partners among people living with HIV: examining the roles of partner characteristics and stigma. AIDS Care 25:566-72
Widman, Laura; Golin, Carol E; Grodensky, Catherine A et al. (2013) Do safer sex self-efficacy, attitudes toward condoms, and HIV transmission risk beliefs differ among men who have sex with men, heterosexual men, and women living with HIV? AIDS Behav 17:1873-82
Chariyeva, Zulfiya; Golin, Carol E; Earp, Jo Anne et al. (2013) The role of self-efficacy and motivation to explain the effect of motivational interviewing time on changes in risky sexual behavior among people living with HIV: a mediation analysis. AIDS Behav 17:813-23
Golin, Carol E; Earp, Jo Anne; Grodensky, Catherine A et al. (2012) Longitudinal effects of SafeTalk, a motivational interviewing-based program to improve safer sex practices among people living with HIV/AIDS. AIDS Behav 16:1182-91
Chariyeva, Zulfiya; Golin, Carol E; Earp, Jo Anne et al. (2012) Does motivational interviewing counseling time influence HIV-positive persons' self-efficacy to practice safer sex? Patient Educ Couns 87:101-7

Showing the most recent 10 out of 12 publications