Despite the significant morbidity of bipolar disorder (BPD) and its high prevalence during the childbearing years, remarkably little is known about the impact of the female reproductive life cycle on BPD. Clinicians lack evidence-based guidelines for the perinatal management of BPD. The proposal addresses an understudied area with considerable public health implications for the estimated 100,000 women with BPD who conceive each year in the US. The broad goal of this project is to delineate the clinical, psychosocial, and in particular, pharmacologic predictors of BPD recurrence during pregnancy. Preliminary findings suggest that inadequate treatment is a particularly robust predictor of prenatal BPD recurrence. Consequently, a specific emphasis will be placed on investigating the recurrence risk associated with suboptimal pharmacotherapy occurring as a result of medication discontinuation or declining drug concentrations secondary to increased prenatal clearance. A prospective cohort design with monthly assessments will be implemented in a collaborative investigation between two of the leading perinatal psychiatry academic centers in the US with specific expertise in mood disorders research during pregnancy.
The specific aims are 1) to quantify the risks for both syndromal and subsyndromal prenatal BPD illness associated with suboptimal pharmacotherapy while controlling for the severity of the previous course of illness and recent psychosocial stressors, 2) to examine the association of maternal prenatal BPD morbidity and psychotropic exposure with infant outcome at delivery thereby filling a current void and rounding out the requisite facets of the clinical risk/benefit assessment, and 3) to conduct pharmacokinetic (PK) modeling in an effort to delineate pregnancyassociated changes in drug clearance and provide initial reliable estimates of fetal drug exposure. Study results will represent an incremental advance that: 1) elucidates risk factors for BPD morbidity during pregnancy; 2) contributes clinically relevant data to establish therapeutic guidelines for BPD during pregnancy; and 3) serve as a basis for preventive strategies aimed at optimizing maternal and infant outcome. Furthermore, the novel PK data will expand our understanding of prenatal drug metabolism, and the project will establish a cohort of children of women with BPD with detailed prospective prenatal histories.
| Camsar?, Ulas; Viguera, Adele C; Ralston, Laurel et al. (2014) Prevalence of atypical antipsychotic use in psychiatric outpatients: comparison of women of childbearing age with men. Arch Womens Ment Health 17:583-6 |
| Polepally, Akshanth R; Pennell, Page B; Brundage, Richard C et al. (2014) MODEL-BASED LAMOTRIGINE CLEARANCE CHANGES DURING PREGNANCY: CLINICAL IMPLICATION. Ann Clin Transl Neurol 1:99-106 |
| Newport, D Jeffrey; Baldessarini, Ross J; Knight, Bettina T et al. (2012) Comparison of women with confirmed versus presumably misdiagnosed bipolar disorder. J Clin Psychiatry 73:242-6 |
| Viguera, Adele C; Tondo, Leonardo; Koukopoulos, Alexia E et al. (2011) Episodes of mood disorders in 2,252 pregnancies and postpartum periods. Am J Psychiatry 168:1179-85 |
| Viguera, Adele C; Cohen, Lee S; Whitfield, Theodore et al. (2010) Perinatal use of anticonvulsants: differences in attitudes and recommendations among neurologists and psychiatrists. Arch Womens Ment Health 13:175-8 |
| Trede, Katharina; Baldessarini, Ross J; Viguera, Adele C et al. (2009) Treatise on insanity in pregnant, postpartum, and lactating women (1858) by Louis-Victor Marce: a commentary. Harv Rev Psychiatry 17:157-65 |
| Viguera, Adele C; Whitfield, Theodore; Baldessarini, Ross J et al. (2007) Risk of recurrence in women with bipolar disorder during pregnancy: prospective study of mood stabilizer discontinuation. Am J Psychiatry 164:1817-24;quiz 1923 |
