The proposed project, submitted in response to PA-04-085 will study cognitive and behavioral functioning in children with DSM-IV Autistic Disorder who also manifest symptoms of Attention Deficit Hyperactivitv Disorder (ADHD). Although the DSM-IV does not specifically allow for a comorbid diagnosis of ADHD with Autism, many children with Autism manifest symptoms of ADHD, and many are treated for it. There have been few studies on ADHD in Autism, so little is known about its cognitive and behavioral manifestations, or the optimal parameters for treatment. The proposed project will address these issues by examining cognitive and behavioral functioning in children with Autism who manifest symptoms of ADHD, as well as their response to stimulant medication treatment. Building upon techniques developed in the PI's previous NIMH-funded studies (MH044118 and MH48212, DA Pearson, PI) as well as her collaborative work in a current NICHD autism program project (HD035471; KA Loveland, PI; DA Pearson, Co-lnv.), this proposed study will address two Specific Aims.
In Specific Aim 1, cognitive and behavioral functioning as well as comorbid psychiatric symptomatology will be compared in: 1) children with Autism who manifest symptoms of ADHD (""""""""Autism/ADHD""""""""), and 2) children with Autism who do not manifest symptoms of ADHD (""""""""Autism/non-ADHD""""""""). In both groups, children will be 7-12 years old, with an IQ of 50-130. It is hypothesized that relative to children, children in the Autism/non-ADHD group, with Autism/ADHD will have greater deficits in attention and inhibition, as well as more internalizing and externalizing psychiatric symptomatology.
In Specific Aim 2, the cognitive and behavioral response to placebo, low, medium, and high doses of methylphenidate (MPH) in children with Autism/ADHD will be studied in a medication treatment trial, using a double-blind, placebo-controlled, crossover design to determine optimal MPH dosages. It is hypothesized that higher MPH doses will produce successive improvements in cognitive and behavioral functioning in children with Autism/ADHD. Thus, the primary goals of the proposed research are to characterize ADHD in school-aged children with Autistic Disorder (DSM-IV), and to assess their cognitive and behavioral response to MPH.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH072263-04
Application #
7422264
Study Section
Child Psychopathology and Developmental Disabilities Study Section (CPDD)
Program Officer
Gilotty, Lisa
Project Start
2005-07-12
Project End
2010-05-31
Budget Start
2008-06-01
Budget End
2009-05-31
Support Year
4
Fiscal Year
2008
Total Cost
$273,390
Indirect Cost
Name
University of Texas Health Science Center Houston
Department
Psychiatry
Type
Schools of Medicine
DUNS #
800771594
City
Houston
State
TX
Country
United States
Zip Code
77225
Mansour, Rosleen; Dovi, Allison T; Lane, David M et al. (2017) ADHD severity as it relates to comorbid psychiatric symptomatology in children with Autism Spectrum Disorders (ASD). Res Dev Disabil 60:52-64
Reynolds, Katharine C; Patriquin, Michelle; Alfano, Candice A et al. (2017) Parent-Reported Problematic Sleep Behaviors in Children with Comorbid Autism Spectrum Disorder and Attention-Deficit/Hyperactivity Disorder. Res Autism Spectr Disord 39:20-32
Dickerson, Aisha S; Pearson, Deborah A; Loveland, Katherine A et al. (2014) Role of parental occupation in autism spectrum disorder diagnosis and severity. Res Autism Spectr Disord 8:997-1007
Pearson, Deborah A; Santos, Cynthia W; Aman, Michael G et al. (2013) Effects of extended release methylphenidate treatment on ratings of attention-deficit/hyperactivity disorder (ADHD) and associated behavior in children with autism spectrum disorders and ADHD symptoms. J Child Adolesc Psychopharmacol 23:337-51
Coskun, Mehmet Akif; Loveland, Katherine A; Pearson, Deborah A et al. (2013) Functional assays of local connectivity in the somatosensory cortex of individuals with autism. Autism Res 6:190-200
Coskun, Mehmet A; Loveland, Katherine A; Pearson, Deborah A et al. (2013) Interaction of finger representations in the cortex of individuals with autism: a functional window into cortical inhibition. Autism Res 6:542-9
Pearson, Deborah A; Aman, Michael G; Arnold, L Eugene et al. (2012) High concordance of parent and teacher attention-deficit/hyperactivity disorder ratings in medicated and unmedicated children with autism spectrum disorders. J Child Adolesc Psychopharmacol 22:284-91
Sheth, Bhavin R; Liu, James; Olagbaju, Olayemi et al. (2011) Detecting social and non-social changes in natural scenes: performance of children with and without autism spectrum disorders and typical adults. J Autism Dev Disord 41:434-46
Pearson, Deborah A; Loveland, Katherine A; Lachar, David et al. (2006) A comparison of behavioral and emotional functioning in children and adolescents with Autistic Disorder and PDD-NOS. Child Neuropsychol 12:321-33