The primary objective of this revised application is to examine the effects of varying degrees of stress in the timing and duration of institutionalization on the development of amygdala and hippocampal structure and function in children adopted from orphanages abroad. The Department of State estimates tens of thousands of children are now being adopted from orphanages abroad each year. With this growing number of adopted children in the U.S., has come increasing concern on the long-term consequences of such early experiences on development. The proposed program of research is based on a cohort of children who have been adopted to the New York metropolitan area over the past decade and who are now between 6 and 11 years of age. We are using behavioral and noninvasive biological measures of the limbic-hypothalamic-pituitary-adrenal (LHPA) axis with emphasis on imaging based measures of amygdala and hippocampal structure and function. Children with varying exposures to institutionalization (duration) will be compared to a control group as well as to each other, as they may be their own best controls with regard to environmental factors inherent in human """"""""deprivation"""""""" studies. We will recruit a typically developing population of children to assess deviations or delays in the development of amygdala and hippocampal volume and function. ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH073175-03
Application #
7068611
Study Section
Biobehavioral Mechanisms of Emotion, Stress and Health Study Section (MESH)
Program Officer
Rumsey, Judith M
Project Start
2004-07-23
Project End
2009-05-31
Budget Start
2006-06-01
Budget End
2007-05-31
Support Year
3
Fiscal Year
2006
Total Cost
$404,334
Indirect Cost
Name
Weill Medical College of Cornell University
Department
Psychiatry
Type
Schools of Medicine
DUNS #
060217502
City
New York
State
NY
Country
United States
Zip Code
10065
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Malter Cohen, M; Tottenham, N; Casey, B J (2013) Translational developmental studies of stress on brain and behavior: implications for adolescent mental health and illness? Neuroscience 249:53-62
Eigsti, Inge-Marie; Weitzman, Carol; Schuh, Jillian et al. (2011) Language and cognitive outcomes in internationally adopted children. Dev Psychopathol 23:629-46
Tottenham, N; Hare, T A; Millner, A et al. (2011) Elevated amygdala response to faces following early deprivation. Dev Sci 14:190-204
Tottenham, Nim; Hare, Todd A; Casey, B J (2011) Behavioral assessment of emotion discrimination, emotion regulation, and cognitive control in childhood, adolescence, and adulthood. Front Psychol 2:39
Casey, B J; Ruberry, Erika J; Libby, Victoria et al. (2011) Transitional and translational studies of risk for anxiety. Depress Anxiety 28:18-28
Tottenham, Nim; Hare, Todd A; Quinn, Brian T et al. (2010) Prolonged institutional rearing is associated with atypically large amygdala volume and difficulties in emotion regulation. Dev Sci 13:46-61
Somerville, Leah H; Jones, Rebecca M; Casey, B J (2010) A time of change: behavioral and neural correlates of adolescent sensitivity to appetitive and aversive environmental cues. Brain Cogn 72:124-33
Casey, B J; Jones, Rebecca M; Levita, Liat et al. (2010) The storm and stress of adolescence: insights from human imaging and mouse genetics. Dev Psychobiol 52:225-35
Casey, B J; Glatt, C E; Tottenham, N et al. (2009) Brain-derived neurotrophic factor as a model system for examining gene by environment interactions across development. Neuroscience 164:108-20

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