Since 1993, the Centers for Disease Control and Prevention (CDC) has recommended routine HIV counseling, testing, and referral (HIV CTR) in US hospitals with an HIV prevalence >1%. Over the past 11 years, these guidelines have been revised and reiterated but they have not successfully been incorporated into standards of care; an estimated 310,000 persons are living in the US with undiagnosed HIV infection. One obstacle to broader adherence to national standards is that the guidelines fail to address the practical question of who should do the testing: Can busy providers add HIV CTR to their practice or must additional support services be provided? Keying off the Systems Model of Clinical Preventive Care and its emphasis on both provider and patient factors in determining the success of preventive behaviors, we propose to study alternative approaches to the delivery of HIV CTR in an urban hospital emergency department (ED) setting. Our two specific aims are: 1) To conduct a randomized, controlled trial of rapid HIV testing comparing ED provider-based testing with HIV counselor-based testing. We will identify: a) The strategy that maximizes the acceptability of HIV testing to patients b) The strategy that maximizes linkage to care among detected, HIV-infected patients 2) To evaluate the cost-effectiveness of the alternative HIV CTR strategies We will examine the intersection of provider and counselor predisposing, enabling and reinforcing factors with trial outcomes of HIV test offer, acceptance, and linkage to care rates. Clinical and economic evaluation will inform policies to promote routine HIV CTR as standard practice. Led by Rochelle P. Walensky, MD, MPH, the project team has an extensive track record of successful routine HIV CTR program design, effective HIV diagnosis and linkage to care, and HIV CTR economic evaluation. The scientific basis for early detection of HIV infection and aggressive linkage to care has been successfully laid. The challenge now is to identify effective, affordable, and cost-effective implementation mechanisms. ? ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
1R01MH073445-01A2
Application #
7119922
Study Section
Behavioral and Social Science Approaches to Preventing HIV/AIDS Study Section (BSPH)
Program Officer
Forsyth, Andrew D
Project Start
2006-08-04
Project End
2011-07-31
Budget Start
2006-08-04
Budget End
2007-07-31
Support Year
1
Fiscal Year
2006
Total Cost
$653,738
Indirect Cost
Name
Massachusetts General Hospital
Department
Type
DUNS #
073130411
City
Boston
State
MA
Country
United States
Zip Code
02199
Ramirez-Avila, Lynn; Regan, Susan; Cloete, Christie et al. (2017) Adolescent Linkage to Care After a Large-scale Transfer From a Hospital-based HIV Clinic to the Public Sector in South Africa. Pediatr Infect Dis J 36:311-313
Bassett, Ingrid V; Regan, Susan; Mbonambi, Hlengiwe et al. (2015) Finding HIV in hard to reach populations: mobile HIV testing and geospatial mapping in Umlazi township, Durban, South Africa. AIDS Behav 19:1888-95
Ramirez-Avila, Lynn; Regan, Susan; Chetty, Senica et al. (2015) HIV testing rates, prevalence, and knowledge among outpatients in Durban, South Africa: Time trends over four years. Int J STD AIDS 26:704-9
Drain, Paul K; Losina, Elena; Coleman, Sharon M et al. (2015) Social support and mental health among adults prior to HIV counseling and testing in Durban, South Africa. AIDS Care 27:1231-40
Drain, P K; Kleene, J M; Coleman, S M et al. (2015) Prevalence of cryptococcal antigenuria at initial HIV diagnosis in KwaZulu-Natal. HIV Med 16:640-4
Drain, Paul K; Losina, Elena; Coleman, Sharon M et al. (2014) Diagnostic accuracy of a point-of-care urine test for tuberculosis screening among newly-diagnosed HIV-infected adults: a prospective, clinic-based study. BMC Infect Dis 14:110
Bassett, Ingrid V; Govindasamy, Darshini; Erlwanger, Alison S et al. (2014) Mobile HIV screening in Cape Town, South Africa: clinical impact, cost and cost-effectiveness. PLoS One 9:e85197
Bassett, I V; Regan, S; Luthuli, P et al. (2014) Linkage to care following community-based mobile HIV testing compared with clinic-based testing in Umlazi Township, Durban, South Africa. HIV Med 15:367-72
Cloete, Christie; Regan, Susan; Giddy, Janet et al. (2014) The Linkage Outcomes of a Large-scale, Rapid Transfer of HIV-infected Patients From Hospital-based to Community-based Clinics in South Africa. Open Forum Infect Dis 1:ofu058
Bogart, Laura M; Chetty, Senica; Giddy, Janet et al. (2013) Barriers to care among people living with HIV in South Africa: contrasts between patient and healthcare provider perspectives. AIDS Care 25:843-53

Showing the most recent 10 out of 47 publications