Our goal is to develop an epidemiological basis for integrated management of diabetes, depressive illness, and associated clinical and behavioral risk factors. Persons with diabetes depression co-morbidity are more likely to have diabetes complications, poorer clinical control, increased behavioral risk factors, and increased disability. The proposed research will provide an empirical basis for an integrated, biopsychosocial approach for care of the two million Americans afflicted by diabetes and major depression. This research will build on a completed survey of 4839 persons with diabetes in Group Health Cooperative (GHC) that assessed diabetes care, depression, disability, and associated risk factors for diabetes and heart disease. We will carry out a 5-year follow-up survey with all survivors to assess depression and disability outcomes, and patient priorities for their care. We will use GHC and Washington State death records to measure mortality. Glycemic, blood pressure, and lipid control, diabetic complications, and quality of health care will be monitored over the five-year follow-up period using GHC medical records. The research goal will be achieved by accomplishing three aims:
Aim 1 : Assess predictors of adverse outcomes - We will develop risk-prediction models for the incidence of adverse outcomes including: 5-year all-cause mortality, coronary disease (CAD) and cerebrovascular (CVA) mortality, incident microvascular and macrovascular complications, poor clinical control (glycemic, blood pressure and lipid control), deterioration in activities of daily living and major depression. A major focus will be the contribution of depression to adverse diabetes outcomes.
Aim 2 : Identify disparities in health care for depressed vs. non-depressed persons with diabetes. We will assess whether depression-diabetes co-morbidity is associated with disparities in the quality of health care for: clinical control (glycemic, blood pressure and lipid control); preventive screening and treatment; and for behavioral risk factor reduction (interventions for obesity, sedentary lifestyle, and smoking cessation).
Aim 3 : Set priorities for integrated services - We will assess criteria relevant to priorities for integrated management of diabetes, depression and associated behavioral risk factors. ? ?

National Institute of Health (NIH)
National Institute of Mental Health (NIMH)
Research Project (R01)
Project #
Application #
Study Section
Services Research Review Committee (SRV)
Program Officer
Oliver, Karen Anderson
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Group Health Cooperative
United States
Zip Code
Katon, Wayne J; Young, Bessie A; Russo, Joan et al. (2013) Association of depression with increased risk of severe hypoglycemic episodes in patients with diabetes. Ann Fam Med 11:245-50
Coleman, Shane M; Katon, Wayne; Lin, Elizabeth et al. (2013) Depression and death in diabetes; 10-year follow-up of all-cause and cause-specific mortality in a diabetic cohort. Psychosomatics 54:428-36
Davydow, Dimitry S; Katon, Wayne J; Lin, Elizabeth H B et al. (2013) Depression and risk of hospitalizations for ambulatory care-sensitive conditions in patients with diabetes. J Gen Intern Med 28:921-9
Huang, Hsiang; Russo, Joan; Von Korff, Michael et al. (2012) The effect of changes in depressive symptoms on disability status in patients with diabetes. Psychosomatics 53:21-9
Davydow, Dimitry S; Hough, Catherine L; Russo, Joan E et al. (2012) The association between intensive care unit admission and subsequent depression in patients with diabetes. Int J Geriatr Psychiatry 27:22-30
Sieu, Nida; Katon, Wayne; Lin, Elizabeth H B et al. (2011) Depression and incident diabetic retinopathy: a prospective cohort study. Gen Hosp Psychiatry 33:429-35
Davydow, Dimitry S; Russo, Joan E; Ludman, Evette et al. (2011) The association of comorbid depression with intensive care unit admission in patients with diabetes: a prospective cohort study. Psychosomatics 52:117-26
Heckbert, Susan R; Rutter, Carolyn M; Oliver, Malia et al. (2010) Depression in relation to long-term control of glycemia, blood pressure, and lipids in patients with diabetes. J Gen Intern Med 25:524-9
Ludman, Evette J; Russo, Joan E; Katon, Wayne J et al. (2010) How does change in depressive symptomatology influence weight change in patients with diabetes? Observational results from the Pathways longitudinal cohort. J Gerontol A Biol Sci Med Sci 65:93-8
Williams, Lisa H; Rutter, Carolyn M; Katon, Wayne J et al. (2010) Depression and incident diabetic foot ulcers: a prospective cohort study. Am J Med 123:748-754.e3

Showing the most recent 10 out of 20 publications