The capacity to acquire and retrieve memories of unique events is termed 'episodic memory'. Impairments of episodic memory are prominent in numerous neurological conditions. Episodic memory dysfunction is also found in major psychiatric disorders, including schizophrenia and depression. The characterization of episodic memory impairments, elucidation of their roles in the etiology of different disorders, and the development of remedial measures, require an understanding of the cognitive operations that support episodic memory and their neural underpinnings. The proposed research will contribute to this understanding by investigating episodic memory encoding-the processes engaged when an event is experienced that result in a durable memory for the event. Functional magnetic resonance imaging will be employed to investigate event-related neural activity that is predictive of whether or not the event will be later remembered. Such differences in neural activity are termed 'subsequent memory effects', and are candidate neural correlates of successful encoding. Experiments will be conducted to investigate: i) encoding of semantically vs. non-semantically mediated item-context associations; ii) encoding of single versus multiple contextual attributes; iii) study-test compatibility effects; iv) general vs. domain-specific interference with encoding; v) the relationship between pre- and post-stimulus subsequent memory effects.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH074528-03
Application #
7261235
Study Section
Cognition and Perception Study Section (CP)
Program Officer
Osborn, Bettina D
Project Start
2005-08-15
Project End
2009-07-31
Budget Start
2007-08-01
Budget End
2008-07-31
Support Year
3
Fiscal Year
2007
Total Cost
$196,291
Indirect Cost
Name
University of California Irvine
Department
Other Basic Sciences
Type
Schools of Arts and Sciences
DUNS #
046705849
City
Irvine
State
CA
Country
United States
Zip Code
92697
Koen, Joshua D; Thakral, Preston P; Rugg, Michael D (2018) Transcranial magnetic stimulation of the left angular gyrus during encoding does not impair associative memory performance. Cogn Neurosci 9:127-138
Koen, Joshua D; Rugg, Michael D (2016) Memory Reactivation Predicts Resistance to Retroactive Interference: Evidence from Multivariate Classification and Pattern Similarity Analyses. J Neurosci 36:4389-99
de Chastelaine, Marianne; Rugg, Michael D (2015) The effects of study task on prestimulus subsequent memory effects in the hippocampus. Hippocampus 25:1217-23
Addante, Richard James; de Chastelaine, Marianne; Rugg, Michael D (2015) Pre-stimulus neural activity predicts successful encoding of inter-item associations. Neuroimage 105:21-31
de Chastelaine, Marianne; Rugg, Michael D (2014) The relationship between task-related and subsequent memory effects. Hum Brain Mapp 35:3687-700
Mattson, Julia T; Wang, Tracy H; de Chastelaine, Marianne et al. (2014) Effects of age on negative subsequent memory effects associated with the encoding of item and item-context information. Cereb Cortex 24:3322-33
Wong, Jenny X; de Chastelaine, Marianne; Rugg, Michael D (2013) Comparison of the neural correlates of encoding item-item and item-context associations. Front Hum Neurosci 7:436
Rugg, Michael D; Vilberg, Kaia L; Mattson, Julia T et al. (2012) Item memory, context memory and the hippocampus: fMRI evidence. Neuropsychologia 50:3070-9
Gottlieb, Lauren J; Wong, Jenny; de Chastelaine, Marianne et al. (2012) Neural correlates of the encoding of multimodal contextual features. Learn Mem 19:605-14
Park, Heekyeong; Rugg, Michael D (2011) Neural correlates of encoding within- and across-domain inter-item associations. J Cogn Neurosci 23:2533-43

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