Abstract

Maintaining healthy cognitive functions, of which memory is a most important one, is one of the major goals of mental health research. Aging, diseases, stress and injury can lead to cognitive and memory impairments. It is estimated that up to one third of adults will experience a gradual decline in cognitive function known as mild cognitive impairment as they age. Furthermore, risk for Alzheimer

Public Health Relevance

Capitalizing on recent findings from our ongoing project using the rat as an animal model, this project continuation aims at identifying the mechanisms and circuitry of memory enhancement in adult animals and in preventing or rescuing memory decay. The results of these studies may lead to the identification of new therapies that prevent or reverse memory impairments. Preventing or rescuing cognitive and memory loss is a most important goal in mental health research.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH074736-09
Application #
8804283
Study Section
Special Emphasis Panel (ZRG1-IFCN-C (04))
Program Officer
Osborn, Bettina D
Project Start
2005-07-01
Project End
2016-11-30
Budget Start
2014-12-01
Budget End
2015-11-30
Support Year
9
Fiscal Year
2015
Total Cost
$563,004
Indirect Cost
$197,417

  Institution

Name
New York University
Department
Neurology
Type
Schools of Arts and Sciences
DUNS #
041968306
City
New York
State
NY
Country
United States
Zip Code
10012

  Publications

Steinmetz, Adam B; Stern, Sarah A; Kohtz, Amy S et al. (2018) Insulin-Like Growth Factor II Targets the mTOR Pathway to Reverse Autism-Like Phenotypes in Mice. J Neurosci 38:1015-1029
Travaglia, Alessio; Steinmetz, Adam B; Miranda, Janelle M et al. (2018) Mechanisms of critical period in the hippocampus underlie object location learning and memory in infant rats. Learn Mem 25:176-182
Katzman, Aaron; Alberini, Cristina M (2018) NLGN1 and NLGN2 in the prefrontal cortex: their role in memory consolidation and strengthening. Curr Opin Neurobiol 48:122-130
Ye, Xiaojing; Kapeller-Libermann, Dana; Travaglia, Alessio et al. (2017) Direct dorsal hippocampal-prelimbic cortex connections strengthen fear memories. Nat Neurosci 20:52-61
Alberini, Cristina M; Travaglia, Alessio (2017) Infantile Amnesia: A Critical Period of Learning to Learn and Remember. J Neurosci 37:5783-5795
Travaglia, Alessio; Bisaz, Reto; Sweet, Eric S et al. (2017) Erratum: Infantile amnesia reflects a developmental critical period for hippocampal learning. Nat Neurosci 20:1033
Steinmetz, Adam B; Johnson, Sarah A; Iannitelli, Dylan E et al. (2016) Insulin-like growth factor 2 rescues aging-related memory loss in rats. Neurobiol Aging 44:9-21
Travaglia, Alessio; Bisaz, Reto; Cruz, Emmanuel et al. (2016) Developmental changes in plasticity, synaptic, glia and connectivity protein levels in rat dorsal hippocampus. Neurobiol Learn Mem 135:125-138
Travaglia, Alessio; Bisaz, Reto; Sweet, Eric S et al. (2016) Infantile amnesia reflects a developmental critical period for hippocampal learning. Nat Neurosci 19:1225-33
Finsterwald, Charles; Steinmetz, Adam B; Travaglia, Alessio et al. (2015) From Memory Impairment to Posttraumatic Stress Disorder-Like Phenotypes: The Critical Role of an Unpredictable Second Traumatic Experience. J Neurosci 35:15903-15

Showing the most recent 10 out of 29 publications