Neuroimmune factors have been shown to play a role in both normal CNS function and in the cognitive dysfunction associated with CNS disorders that have a neuroinflammatory component. Our knowledge about the neuronal substrates that mediate the cognitive problems associated with neuroinflammation is limited. Progress in this area will require a basic understanding of the interactions between neuroimmune factors and the cellular and molecular mechanisms that mediate normal brain function. The proposed studies focus on this issue as it relates to CNS disorders.
Project Narrative Neuroimmune factors have been shown to play a role in both normal CNS function and in the cognitive dysfunction associated with CNS disorders that have a neuroinflammatory component. Our knowledge about the neuronal substrates that mediate the cognitive problems associated with neuroinflammation is limited. Progress in this area will require a basic understanding of the interactions between neuroimmune factors and the cellular and molecular mechanisms that mediate normal brain function. The proposed studies focus on this issue as it relates to CNS disorders.
| Gruol, Donna L (2015) IL-6 regulation of synaptic function in the CNS. Neuropharmacology 96:42-54 |
| Gruol, Donna L (2013) Neuroimmune regulation of neurophysiology in the cerebellum. Cerebellum 12:307-9 |
| Gruol, Donna; Manto, Mario; Haines, Duane (2012) Ca2+ signaling in cerebellar Purkinje neurons--editorial. Cerebellum 11:605-8 |
| Nelson, T E; Olde Engberink, A; Hernandez, R et al. (2012) Altered synaptic transmission in the hippocampus of transgenic mice with enhanced central nervous systems expression of interleukin-6. Brain Behav Immun 26:959-71 |
| Gruol, D L; Puro, A; Hao, C et al. (2011) Neuroadaptive changes in cerebellar neurons induced by chronic exposure to IL-6. J Neuroimmunol 239:28-36 |
