This application describes an interlocking, two-site collaborative R01 to test the effects of a brief cognitive behavioral therapy (BCBT) protocol for youths (age 8-15) presenting with anxiety and/or depression in primary care. Over a five year period, 210 youths (105 per site) will be randomly assigned to (a) BCBT delivered in primary care or (b) enhanced referral to specialty mental health care (SMHC). This application builds on a preliminary study (N=60), in which a pilot version of BCBT was well-accepted by families and clinicians and was more efficacious than referral to SMHC. We now propose to test BCBT against an enhanced SMHC referral model in a larger, more diverse sample to establish its utility as a community-based intervention. Outcomes will be assessed by independent evaluators blind to participant status at 16 and 32 weeks post- randomization (Aim 1). It is hypothesized that BCBT will be superior to enhanced SMHC referral in terms of overall clinical improvement (CGI-I

Public Health Relevance

This study will test whether a brief (12 week) psychological treatment program, based in primary care, can help youths struggling with depression and anxiety. Impact of the program on symptoms and cost-effectiveness will be measured. This will be the first study to assess if anxiety and depression can be treated with one, simple program, and results may help move effective treatments for these serious problems into community practice.

National Institute of Health (NIH)
National Institute of Mental Health (NIMH)
Research Project (R01)
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Study Section
Interventions Committee for Disorders Involving Children and Their Families (ITVC)
Program Officer
Sherrill, Joel
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San Diego State University
Schools of Arts and Sciences
San Diego
United States
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Schwartz, Karen T G; Bowling, Amanda A; Dickerson, John F et al. (2018) The Child and Adolescent Services Assessment: Interrater Reliability and Predictors of Rater Disagreement. Adm Policy Ment Health 45:944-957
Weersing, V Robin; Jeffreys, Megan; Do, Minh-Chau T et al. (2017) Evidence Base Update of Psychosocial Treatments for Child and Adolescent Depression. J Clin Child Adolesc Psychol 46:11-43
Weersing, V Robin; Brent, David A; Rozenman, Michelle S et al. (2017) Brief Behavioral Therapy for Pediatric Anxiety and Depression in Primary Care: A Randomized Clinical Trial. JAMA Psychiatry 74:571-578
Garber, Judy; Brunwasser, Steven M; Zerr, Argero A et al. (2016) Treatment and Prevention of Depression and Anxiety in Youth: Test of Cross-Over Effects. Depress Anxiety 33:939-959
Jeffreys, Megan; Rozenman, Michelle; Gonzalez, Araceli et al. (2016) Factor Structure of the Parent-Report Mood and Feelings Questionnaire (MFQ) in an Outpatient Mental Health Sample. J Abnorm Child Psychol 44:1111-20
Weersing, V Robin; Rozenman, Michelle S; Maher-Bridge, Maureen et al. (2012) Anxiety, Depression, and Somatic Distress: Developing a Transdiagnostic Internalizing Toolbox for Pediatric Practice. Cogn Behav Pract 19:68-82