Developing new interventions that incorporate the """"""""diverse needs and circumstances of people with mental illness,"""""""" particularly in primary care and community settings, is a key NIMH strategic objective. Prevention of mental disorders has become a priority for the NIMH, which emphasizes the importance of developing """"""""new and better interventions"""""""" to """"""""...preempt the occurrence of disease."""""""" These interventions must (1) work in multiple and diverse settings (e.g. primary care);(2) be suitable for delivery outside of traditional mental health systems (3) use new technologies;(4) build on previous clinical trials;(5) reduce identified disorders/enhance functional outcomes;(6) include families and (7) be tailored to the individual. Despite these NIMH guidelines, while primary care physicians remain the first line providers for at-risk adolescents, there is no widely available, low cost and culturally acceptable preventive approach that targets depression in primary care settings. To address this gap and specified NIMH priority, Dr. Van Voorhees developed and conducted a phase 2 clinical trial of a primary care Internet-based depression prevention intervention (CATCH-IT, Competent Adulthood Transition with Cognitive Behavioral Humanistic and Interpersonal Training). In this study, the high intensity arm (i.e., motivational interview + internet site) demonstrated significant reductions in depressed mood and increases in protective factors (social support, motivation) and lower incidence of depressive episodes over 12 months (7% versus 28%), compared to the low intensity arm (internet site referral + only physician brief advice). We now propose the next step study, a phase 3 efficacy study. In this 5-year, two-site randomized clinical trial, we propose to test the efficacy of the CATCH-IT primary care/Internet based depression prevention intervention against Attention Monitoring Psychoeducation (AMPE) in preventing the onset of depressive episodes in an intermediate to high risk group of adolescents aged 13-17. We plan to (a) identify high risk adolescents based on elevated scores on the PHQ-A, a screening measure of depressive symptoms;(b) recruit 400 (200 per site) of these at-risk adolescents to be randomized into either the CATCH-IT or the AMPE group;(c) assess outcomes at 2, 8, 12, 18, and 24 months post intake on measures of depressive symptoms, depressive diagnoses, other mental disorders, and on measures of role impairment in education, quality of life, attainment of educational milestones, and family functioning;and (d) conduct exploratory analyses to examine the effectiveness of this intervention program, moderators of protection, and potential ethnic and cultural differences in intervention response.

Public Health Relevance

This a randomized clinical trial to determine if a primary care internet-based depression prevention intervention (CATCH-IT 2R) can build resiliency and protect adolescents (ages 13-17) against depression and strengthen their ability to attain their life goals. The intervention includes a motivational interview with the adolescent's primary care physician and learning coping skills through stories, videos and games on-line. Adolescents, who will be randomly assigned to the intervention or an education control groups, will be evaluated for progress over two years.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH090035-03
Application #
8213410
Study Section
Interventions Committee for Disorders Involving Children and Their Families (ITVC)
Program Officer
Goldstein, Amy B
Project Start
2012-02-15
Project End
2016-05-31
Budget Start
2012-06-01
Budget End
2013-05-31
Support Year
3
Fiscal Year
2012
Total Cost
$646,776
Indirect Cost
$129,490
Name
University of Illinois at Chicago
Department
Pediatrics
Type
Schools of Medicine
DUNS #
098987217
City
Chicago
State
IL
Country
United States
Zip Code
60612
Brown, C Hendricks; Brincks, Ahnalee; Huang, Shi et al. (2018) Two-Year Impact of Prevention Programs on Adolescent Depression: an Integrative Data Analysis Approach. Prev Sci 19:74-94
Abuwalla, Zach; Clark, Maureen D; Burke, Brendan et al. (2018) Long-term telemental health prevention interventions for youth: A rapid review. Internet Interv 11:20-29
Gladstone, Tracy; Terrizzi, Daniela; Stinson, Allison et al. (2018) Effect of Internet-based Cognitive Behavioral Humanistic and Interpersonal Training vs. Internet-based General Health Education on Adolescent Depression in Primary Care: A Randomized Clinical Trial. JAMA Netw Open 1:
Bansa, Melishia; Brown, Darryl; DeFrino, Daniela et al. (2018) A Little Effort Can Withstand the Hardship: Fielding an Internet-Based Intervention to Prevent Depression among Urban Racial/Ethnic Minority Adolescents in a Primary Care Setting. J Natl Med Assoc 110:130-142
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Abuwalla, Zach; Kadhem, Zaynab; Gladstone, Tracy et al. (2017) Proposed model for the cultural adaptation of an Internet-based depression prevention intervention (CATCH-IT) for Arab adolescents. Int J Adolesc Med Health :
Mahoney, Nicholas; Gladstone, Tracy; DeFrino, Daniela et al. (2017) Prevention of Adolescent Depression in Primary Care: Barriers and Relational Work Solutions. Calif J Health Promot 15:1-12
Patel, Unnati; Sobowale, Kunmi; Fan, Jingyi et al. (2016) Cultural considerations for the adaptation of an Internet-based intervention for depression prevention in Mainland China. Int J Adolesc Med Health 29:
Richards, Katie; Marko-Holguin, Monika; Fogel, Joshua et al. (2016) RANDOMIZED CLINICAL TRIAL OF AN INTERNET-BASED INTERVENTION TO PREVENT ADOLESCENT DEPRESSION IN A PRIMARY CARE SETTING (CATCH-IT): 2.5-YEAR OUTCOMES. J Evid Based Psychother 16:113-134
Gladstone, Tracy G; Marko-Holguin, Monika; Rothberg, Phyllis et al. (2015) An internet-based adolescent depression preventive intervention: study protocol for a randomized control trial. Trials 16:203

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