Compared to Non-Hispanic Whites, Black Americans carry a disproportionate burden of social risk factors for poor mental health, such as living in violent urban environments and experiencing economic deprivation and discrimination. Despite these risks, Black Americans have lower lifetime prevalence of depressive and anxiety disorders than Whites. The reasons for Black Americans' resilience to these mental health disorders are unknown. This proposal aims to examine cumulative adversity and subsequent diminished neurobiological stress response as a possible explanation of Black Americans' resilience to anxiety and depression. It also aims to investigate the neural mechanisms underlying this resilience.
These aims will be accomplished by conducting research interviews with 1,306 young adults (age 20-21; 60% Black, 40% White; 50% female) from an existing community sample who have been previously assessed three times during childhood and adolescence. These research interviews will provide information on adversity experienced by the participants, categorical diagnoses and dimensional measures of internalizing distress, and physiological indicators of reactivity to stress. Neural bases of stress response will be evaluated with functional magnetic resonance imaging (fMRI) for a subset of 120 Black and 120 White participants from the larger study. This study is innovative because it proposes to test a novel mechanism explaining the resilience of Black Americans to depression and anxiety, incorporates both categorical and dimensional measures of internalizing problems, and examines the role of physiological stress response and regulatory neural circuit in the resilience process. The results will have important implications for our understanding of racial disparities i anxiety and depression, neurobiological mechanisms underlying resilience to stress, and relationships between environmental stress, neural and physiological response, and negative affect. These findings will point to novel ways to diagnose and treat mental health problems in Black and White Americans.

Public Health Relevance

Black Americans are exposed to more adversity than White Americans, yet they experience lower rates of anxiety and depressive disorders. The proposed project investigates cumulative adversity and diminished neurobiological stress response as causal mechanisms underlying Black Americans' resilience to anxiety and mood disorders. The findings will improve our understanding of the role of adversity and neurobiological stress system in anxiety and depression and suggest novel approaches to diagnose and treat these mental health problems in Black and White Americans.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
4R01MH098348-05
Application #
9070767
Study Section
Special Emphasis Panel (ZMH1)
Program Officer
Zehr, Julia L
Project Start
2012-07-10
Project End
2017-06-30
Budget Start
2016-07-01
Budget End
2017-06-30
Support Year
5
Fiscal Year
2016
Total Cost
Indirect Cost
Name
University of Alabama Birmingham
Department
Psychology
Type
Schools of Arts and Sciences
DUNS #
063690705
City
Birmingham
State
AL
Country
United States
Zip Code
35294
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Harnett, Nathaniel G; Shumen, Joshua R; Wagle, Pooja A et al. (2016) Neural mechanisms of human temporal fear conditioning. Neurobiol Learn Mem 136:97-104

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