Early life stress (ELS) is a significant risk factor for the development of a range of psychiatric symptoms that cut across a number of diagnostic categories. The mechanisms through which ELS confers this heightened vulnerability, however, are poorly understood. Given that there are several million referrals involving alleged child maltreatment in the US each year, it is critical that investigators focus on elucidating the neurodevelopmental consequences of ELS and the mechanisms by which ELS-related changes in neurobiological function confer vulnerability for psychopathology. Importantly, epidemiological studies have documented that the transition to puberty is a critical period for the expression of the effects of ELS;moreover, beginning at puberty, there is a higher incidence of symptoms of emotional disorders in females than in males who were abused as young children, suggesting that these outcomes are moderated by gender. Therefore, in efforts to elucidate the effects of ELS on neurobiological systems and on vulnerability for psychopathology, it is vital that researchers consider the impact of both puberty and gender. The proposed project is designed to address these issues, examining the influence of ELS on the maturation of neural circuits and neuroendocrine and cognitive processes that are critical to psychological health, and that are integral to specific RDoC constructs of the Negative Valence, Positive Valence, and Arousal/Regulatory Systems. Because ELS confers vulnerability for a range of psychiatric illnesses, elucidating the effects of ELS on broad domains of function in which aberrations are posited to transect a variety of psychopathologies will allow us to develop a more comprehensive and integrative understanding of how risk for psychopathology emerges and is manifested in children with a history of ELS. Further, findings from this project will inform early interventions aimed at preventing the long-term sequelae of ELS.

Public Health Relevance

Early life stress (ELS) is a significant risk factor for the development of psychiatric symptoms that cut across diagnostic categories. The mechanisms through which ELS confers this heightened vulnerability, however, are poorly understood. Given the enormous number of referrals in the US involving child maltreatment each year, it is imperative that we examine the neurodevelopmental consequences of ELS and the mechanisms by which changes in neurobiological function increase risk for psychopathology. Findings from the proposed project will lead to a more integrative understanding of how risk for psychopathology emerges and is manifested in children with ELS, and will inform early interventions aimed at preventing adverse consequence of ELS.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
1R01MH101495-01
Application #
8573801
Study Section
Special Emphasis Panel (ZMH1-ERB-S (04))
Program Officer
Garriock, Holly A
Project Start
2013-09-01
Project End
2017-08-31
Budget Start
2013-09-01
Budget End
2014-08-31
Support Year
1
Fiscal Year
2013
Total Cost
$624,445
Indirect Cost
$224,531
Name
Stanford University
Department
Psychiatry
Type
Schools of Medicine
DUNS #
009214214
City
Stanford
State
CA
Country
United States
Zip Code
94305
Roth, Marissa C; Humphreys, Kathryn L; King, Lucy S et al. (2018) Self-reported neglect, amygdala volume, and symptoms of anxiety in adolescent boys. Child Abuse Negl 80:80-89
Davis, Elena Goetz; Keller, Jennifer; Hallmayer, Joachim et al. (2018) Corticotropin-releasing factor 1 receptor haplotype and cognitive features of major depression. Transl Psychiatry 8:5
Ho, Tiffany C; Dennis, Emily L; Thompson, Paul M et al. (2018) Network-based approaches to examining stress in the adolescent brain. Neurobiol Stress 8:147-157
Manczak, Erika M; Gotlib, Ian H (2018) Relational Victimization and Telomere Length in Adolescent Girls. J Res Adolesc :
Davis, Elena Goetz; Foland-Ross, Lara C; Gotlib, Ian H (2018) Neural correlates of top-down regulation and generation of negative affect in major depressive disorder. Psychiatry Res Neuroimaging 276:1-8
Ellwood-Lowe, Monica E; Humphreys, Kathryn L; Ordaz, Sarah J et al. (2018) Time-varying effects of income on hippocampal volume trajectories in adolescent girls. Dev Cogn Neurosci 30:41-50
Humphreys, Kathryn L; Watts, Emily L; Dennis, Emily L et al. (2018) Stressful Life Events, ADHD Symptoms, and Brain Structure in Early Adolescence. J Abnorm Child Psychol :
King, Lucy S; Humphreys, Kathryn L; Camacho, M Catalina et al. (2018) A person-centered approach to the assessment of early life stress: Associations with the volume of stress-sensitive brain regions in early adolescence. Dev Psychopathol :1-13
Ho, Tiffany C; King, Lucy S; Leong, Josiah K et al. (2017) Effects of sensitivity to life stress on uncinate fasciculus segments in early adolescence. Soc Cogn Affect Neurosci 12:1460-1469
Ho, Tiffany C; Sacchet, Matthew D; Connolly, Colm G et al. (2017) Inflexible Functional Connectivity of the Dorsal Anterior Cingulate Cortex in Adolescent Major Depressive Disorder. Neuropsychopharmacology 42:2434-2445

Showing the most recent 10 out of 20 publications