Social attachments are a vital part of healthy human behavior and an inability to form such attachments is regarded as a symptom of mental disorders such as anti-social disorders, schizophrenia and autism. Studying the mechanisms underlying social attachment requires an animal model that displays behaviors similar to that of human social attachment. Prairie voles (Microtus ochrogaster) have become an important model for the study of the neurobiology of social attachment. In the field, male and female prairie voles form long-term, monogamous bonds and share a nest throughout the breeding season. Such a breeding pair typically remains together until one animal dies. Given that mating in prairie voles induces neuroadaptations that eventually lead to bonding, we propose here to investigate whether mating induced social bonding has an underlying epigenetic basis. Our preliminary data support this hypothesis.
Prairie voles have become an important model for the study of the neurobiology of social attachment. Given that mating in prairie voles induces adaptations in specific brain regions that eventually lead to bonding, we propose here to investigate some of mechanisms that underlie the development of social bonding in prairie voles. Understanding the mechanisms of social bonding is very relevant to understanding some psychopathologies like autism that impacts 1 in 68 children, antisocial personality disorders and schizophrenia, each having a prevalence rate of 4.5 to 6.8% in North American men.
|Dossat, Amanda M; Wright, Katherine N; Strong, Caroline E et al. (2018) Behavioral and biochemical sensitivity to low doses of ketamine: Influence of estrous cycle in C57BL/6 mice. Neuropharmacology 130:30-41|
|Wright, Katherine N; Kabbaj, Mohamed (2018) Sex differences in sub-anesthetic ketamine's antidepressant effects and abuse liability. Curr Opin Behav Sci 23:36-41|
|Elvir, Lindsay; Duclot, Florian; Wang, Zuoxin et al. (2017) Epigenetic regulation of motivated behaviors by histone deacetylase inhibitors. Neurosci Biobehav Rev :|
|Schoepfer, Kristin J; Strong, Caroline E; Saland, Samantha K et al. (2017) Sex- and dose-dependent abuse liability of repeated subanesthetic ketamine in rats. Physiol Behav :|
|Duclot, Florian; Kabbaj, Mohamed (2017) The Role of Early Growth Response 1 (EGR1) in Brain Plasticity and Neuropsychiatric Disorders. Front Behav Neurosci 11:35|
|Duclot, Florian; Kabbaj, Mohamed (2017) Comparative Transcriptomic Analysis of the Effects of Antidepressant Drugs in Stress-Susceptible Mice. Biol Psychiatry 81:278-279|