Our proposal will investigate how neuronal coordination between the medial frontal cortex (MFC) and the basolateral amygdala (BLA) is causally involved in complex social interactions. We will capitalize on our newly developed social gaze interaction paradigm in pairs of rhesus macaques to understand the neurobiological mechanisms of MFC-BLA coupling, with a goal of working toward generating a macaque model of social dysfunction. We will first determine whether and how the two regions are coordinated during various social gaze events (e.g., looking at the eyes or mutual eye contact). We will then stimulate MFC, BLA or both in order to disrupt the MFC-BLA coordination to induce social gaze deficits. Finally, we will examine whether these disruptions are generalizable to other social domains by testing the impact of perturbing MFC-BLA coordination in a complex social decision-making game. Informed by these results, we hope to investigate in the future how pharmacological (systemic or focal drug manipulations) and behavioral (social interaction manipulations) interventions could effectively restore the inducible social deficits.
Social dysfunctions found in numerous psychiatric disorders, such as autism, psychopathy, social anxiety, and major depressive disorders, are associated with impairments in integrating social information across the frontal cortices and the amygdala. We will investigate the neural mechanisms that guide these interactions and their causal contributions during real-life social gaze interactions by recording neuronal activity and disrupting the neuronal coordination. We will then test the generalizability of these disruptions in a complex social decision- making domain.
| Stanton, Colin H; Holmes, Avram J; Chang, Steve W C et al. (2018) From Stress to Anhedonia: Molecular Processes through Functional Circuits. Trends Neurosci : |
| Dal Monte, Olga; Fan, Siqi; Chang, Steve W C (2018) Social subjective value in the primate midbrain. Nat Neurosci 21:1298-1299 |
| Chang, Steve W C; Dal Monte, Olga (2018) Shining Light on Social Learning Circuits. Trends Cogn Sci 22:673-675 |
| Piva, Matthew; Chang, Steve W C (2018) An integrated framework for the role of oxytocin in multistage social decision-making. Am J Primatol 80:e22735 |
| Dal Monte, Olga; Piva, Matthew; Anderson, Kevin M et al. (2017) Oxytocin under opioid antagonism leads to supralinear enhancement of social attention. Proc Natl Acad Sci U S A 114:5247-5252 |
| Chang, Steve W C (2017) An Emerging Field of Primate Social Neurophysiology: Current Developments. eNeuro 4: |
| Dal Monte, Olga; Piva, Matthew; Morris, Jason A et al. (2016) Live interaction distinctively shapes social gaze dynamics in rhesus macaques. J Neurophysiol 116:1626-1643 |
